Loading…
Cognitive decline and survival in Alzheimer's disease
Objective To test the association of rate of cognitive decline, an indicator of the severity of the underlying disease process, with risk of death in Alzheimer's disease (AD). Methods A total of 472 persons with clinically diagnosed AD were recruited from a memory disorders clinic and day care...
Saved in:
| Published in: | International journal of geriatric psychiatry 2006-04, Vol.21 (4), p.356-362 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4452-690d65af956ad287f6dc3ca19e8e2ec515ad43d3cada460c8842f1410262d8bb3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4452-690d65af956ad287f6dc3ca19e8e2ec515ad43d3cada460c8842f1410262d8bb3 |
| container_end_page | 362 |
| container_issue | 4 |
| container_start_page | 356 |
| container_title | International journal of geriatric psychiatry |
| container_volume | 21 |
| creator | Wilson, Robert S. Li, Yan Aggarwal, Neelum T. McCann, Judy J. Gilley, David W. Bienias, Julia L. Barnes, Lisa L. Evans, Denis A. |
| description | Objective
To test the association of rate of cognitive decline, an indicator of the severity of the underlying disease process, with risk of death in Alzheimer's disease (AD).
Methods
A total of 472 persons with clinically diagnosed AD were recruited from a memory disorders clinic and day care centers in the Chicago area. They completed a uniform clinical evaluation at baseline and a battery of nine cognitive tests at six‐month intervals for a mean of about three years. A previously established measure of global cognition was derived from the nine tests.
Results
During follow‐up, 168 persons (36%) died. In a proportional hazards model that controlled for age, sex, race, education, and baseline level of cognition, individual rate of global cognitive decline, estimated with least squares regression, was linearly related to mortality risk. Thus, a person declining minimally (increase of 0.04 unit per year, 90th percentile) was 2.7 times less likely to die during the study period than a person declining rapidly (decrease of 0.76 unit per year, 10th percentile). Controlling for baseline disability did not substantially affect results. The association of cognitive decline with mortality was substantially stronger for white persons compared to African Americans and in those with less compared to more education.
Conclusion
The results indicate that the rate at which cognition declines in AD is robustly related to survival. Copyright © 2006 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/gps.1472 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67827095</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67827095</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4452-690d65af956ad287f6dc3ca19e8e2ec515ad43d3cada460c8842f1410262d8bb3</originalsourceid><addsrcrecordid>eNqF0VtrFDEUB_BQlHZ7AT-BDEKrL1NzMrnNY1nqKr2JVgRfQjY5U1NnZ7bJzmr76U3ZwYIgPh3I-XEO5x9CXgA9BkrZ25tlOgau2BaZAK3rEkDKZ2RCtRalZBXdIbsp3VKae6C3yQ5IUXGlqgkR0_6mC6uwxsKja0OHhe18kYa4DmvbFqErTtqH7xgWGF-nwoeENuE-ed7YNuHBWPfIl3en19P35fnV7MP05Lx0nAtWypp6KWxTC2k906qR3lXOQo0aGToBwnpe-fzkLZfUac1ZAxwok8zr-bzaI0ebucvY3w2YVmYRksO2tR32QzJSaaZoLf4LGYCg-fYMX_0Fb_shdvkIwxgVoDjwjN5skIt9ShEbs4xhYeO9AWoeAzc5cPMYeKYvx3nDfIH-CY4JZ3A4ApucbZtoOxfSk1NSqfxP2ZUb9zO0eP_PhWb28fO4ePQhrfDXH2_jj5xKpYT5ejkzFwCfzhST5lv1G1Xzo2E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220517414</pqid></control><display><type>article</type><title>Cognitive decline and survival in Alzheimer's disease</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Wilson, Robert S. ; Li, Yan ; Aggarwal, Neelum T. ; McCann, Judy J. ; Gilley, David W. ; Bienias, Julia L. ; Barnes, Lisa L. ; Evans, Denis A.</creator><creatorcontrib>Wilson, Robert S. ; Li, Yan ; Aggarwal, Neelum T. ; McCann, Judy J. ; Gilley, David W. ; Bienias, Julia L. ; Barnes, Lisa L. ; Evans, Denis A.</creatorcontrib><description>Objective
To test the association of rate of cognitive decline, an indicator of the severity of the underlying disease process, with risk of death in Alzheimer's disease (AD).
Methods
A total of 472 persons with clinically diagnosed AD were recruited from a memory disorders clinic and day care centers in the Chicago area. They completed a uniform clinical evaluation at baseline and a battery of nine cognitive tests at six‐month intervals for a mean of about three years. A previously established measure of global cognition was derived from the nine tests.
Results
During follow‐up, 168 persons (36%) died. In a proportional hazards model that controlled for age, sex, race, education, and baseline level of cognition, individual rate of global cognitive decline, estimated with least squares regression, was linearly related to mortality risk. Thus, a person declining minimally (increase of 0.04 unit per year, 90th percentile) was 2.7 times less likely to die during the study period than a person declining rapidly (decrease of 0.76 unit per year, 10th percentile). Controlling for baseline disability did not substantially affect results. The association of cognitive decline with mortality was substantially stronger for white persons compared to African Americans and in those with less compared to more education.
Conclusion
The results indicate that the rate at which cognition declines in AD is robustly related to survival. Copyright © 2006 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.1472</identifier><identifier>PMID: 16534773</identifier><identifier>CODEN: IJGPES</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; African Americans ; Aged ; Aged, 80 and over ; Alzheimer Disease - mortality ; Alzheimer's disease ; Biological and medical sciences ; Chicago - epidemiology ; cognition ; Cognition & reasoning ; Cognition Disorders - epidemiology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Educational Status ; European Continental Ancestry Group ; Female ; Fundamental and applied biological sciences. Psychology ; Geriatric psychiatry ; Geriatrics ; Humans ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; mortality ; Neurology ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; race ; Regression analysis ; Survival analysis ; White people</subject><ispartof>International journal of geriatric psychiatry, 2006-04, Vol.21 (4), p.356-362</ispartof><rights>Copyright © 2006 John Wiley & Sons, Ltd.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright (c) 2006 John Wiley & Sons, Ltd.</rights><rights>Copyright John Wiley and Sons, Limited Apr 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4452-690d65af956ad287f6dc3ca19e8e2ec515ad43d3cada460c8842f1410262d8bb3</citedby><cites>FETCH-LOGICAL-c4452-690d65af956ad287f6dc3ca19e8e2ec515ad43d3cada460c8842f1410262d8bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17677088$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16534773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilson, Robert S.</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Aggarwal, Neelum T.</creatorcontrib><creatorcontrib>McCann, Judy J.</creatorcontrib><creatorcontrib>Gilley, David W.</creatorcontrib><creatorcontrib>Bienias, Julia L.</creatorcontrib><creatorcontrib>Barnes, Lisa L.</creatorcontrib><creatorcontrib>Evans, Denis A.</creatorcontrib><title>Cognitive decline and survival in Alzheimer's disease</title><title>International journal of geriatric psychiatry</title><addtitle>Int. J. Geriat. Psychiatry</addtitle><description>Objective
To test the association of rate of cognitive decline, an indicator of the severity of the underlying disease process, with risk of death in Alzheimer's disease (AD).
Methods
A total of 472 persons with clinically diagnosed AD were recruited from a memory disorders clinic and day care centers in the Chicago area. They completed a uniform clinical evaluation at baseline and a battery of nine cognitive tests at six‐month intervals for a mean of about three years. A previously established measure of global cognition was derived from the nine tests.
Results
During follow‐up, 168 persons (36%) died. In a proportional hazards model that controlled for age, sex, race, education, and baseline level of cognition, individual rate of global cognitive decline, estimated with least squares regression, was linearly related to mortality risk. Thus, a person declining minimally (increase of 0.04 unit per year, 90th percentile) was 2.7 times less likely to die during the study period than a person declining rapidly (decrease of 0.76 unit per year, 10th percentile). Controlling for baseline disability did not substantially affect results. The association of cognitive decline with mortality was substantially stronger for white persons compared to African Americans and in those with less compared to more education.
Conclusion
The results indicate that the rate at which cognition declines in AD is robustly related to survival. Copyright © 2006 John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>African Americans</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - mortality</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Chicago - epidemiology</subject><subject>cognition</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - epidemiology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Educational Status</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Geriatric psychiatry</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mortality</subject><subject>Neurology</subject><subject>Psychoanalysis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>race</subject><subject>Regression analysis</subject><subject>Survival analysis</subject><subject>White people</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqF0VtrFDEUB_BQlHZ7AT-BDEKrL1NzMrnNY1nqKr2JVgRfQjY5U1NnZ7bJzmr76U3ZwYIgPh3I-XEO5x9CXgA9BkrZ25tlOgau2BaZAK3rEkDKZ2RCtRalZBXdIbsp3VKae6C3yQ5IUXGlqgkR0_6mC6uwxsKja0OHhe18kYa4DmvbFqErTtqH7xgWGF-nwoeENuE-ed7YNuHBWPfIl3en19P35fnV7MP05Lx0nAtWypp6KWxTC2k906qR3lXOQo0aGToBwnpe-fzkLZfUac1ZAxwok8zr-bzaI0ebucvY3w2YVmYRksO2tR32QzJSaaZoLf4LGYCg-fYMX_0Fb_shdvkIwxgVoDjwjN5skIt9ShEbs4xhYeO9AWoeAzc5cPMYeKYvx3nDfIH-CY4JZ3A4ApucbZtoOxfSk1NSqfxP2ZUb9zO0eP_PhWb28fO4ePQhrfDXH2_jj5xKpYT5ejkzFwCfzhST5lv1G1Xzo2E</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Wilson, Robert S.</creator><creator>Li, Yan</creator><creator>Aggarwal, Neelum T.</creator><creator>McCann, Judy J.</creator><creator>Gilley, David W.</creator><creator>Bienias, Julia L.</creator><creator>Barnes, Lisa L.</creator><creator>Evans, Denis A.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>Cognitive decline and survival in Alzheimer's disease</title><author>Wilson, Robert S. ; Li, Yan ; Aggarwal, Neelum T. ; McCann, Judy J. ; Gilley, David W. ; Bienias, Julia L. ; Barnes, Lisa L. ; Evans, Denis A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4452-690d65af956ad287f6dc3ca19e8e2ec515ad43d3cada460c8842f1410262d8bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>African Americans</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - mortality</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Chicago - epidemiology</topic><topic>cognition</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders - epidemiology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Educational Status</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Geriatric psychiatry</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>mortality</topic><topic>Neurology</topic><topic>Psychoanalysis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>race</topic><topic>Regression analysis</topic><topic>Survival analysis</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilson, Robert S.</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Aggarwal, Neelum T.</creatorcontrib><creatorcontrib>McCann, Judy J.</creatorcontrib><creatorcontrib>Gilley, David W.</creatorcontrib><creatorcontrib>Bienias, Julia L.</creatorcontrib><creatorcontrib>Barnes, Lisa L.</creatorcontrib><creatorcontrib>Evans, Denis A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilson, Robert S.</au><au>Li, Yan</au><au>Aggarwal, Neelum T.</au><au>McCann, Judy J.</au><au>Gilley, David W.</au><au>Bienias, Julia L.</au><au>Barnes, Lisa L.</au><au>Evans, Denis A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive decline and survival in Alzheimer's disease</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int. J. Geriat. Psychiatry</addtitle><date>2006-04</date><risdate>2006</risdate><volume>21</volume><issue>4</issue><spage>356</spage><epage>362</epage><pages>356-362</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><coden>IJGPES</coden><abstract>Objective
To test the association of rate of cognitive decline, an indicator of the severity of the underlying disease process, with risk of death in Alzheimer's disease (AD).
Methods
A total of 472 persons with clinically diagnosed AD were recruited from a memory disorders clinic and day care centers in the Chicago area. They completed a uniform clinical evaluation at baseline and a battery of nine cognitive tests at six‐month intervals for a mean of about three years. A previously established measure of global cognition was derived from the nine tests.
Results
During follow‐up, 168 persons (36%) died. In a proportional hazards model that controlled for age, sex, race, education, and baseline level of cognition, individual rate of global cognitive decline, estimated with least squares regression, was linearly related to mortality risk. Thus, a person declining minimally (increase of 0.04 unit per year, 90th percentile) was 2.7 times less likely to die during the study period than a person declining rapidly (decrease of 0.76 unit per year, 10th percentile). Controlling for baseline disability did not substantially affect results. The association of cognitive decline with mortality was substantially stronger for white persons compared to African Americans and in those with less compared to more education.
Conclusion
The results indicate that the rate at which cognition declines in AD is robustly related to survival. Copyright © 2006 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>16534773</pmid><doi>10.1002/gps.1472</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-6230 |
| ispartof | International journal of geriatric psychiatry, 2006-04, Vol.21 (4), p.356-362 |
| issn | 0885-6230 1099-1166 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67827095 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult African Americans Aged Aged, 80 and over Alzheimer Disease - mortality Alzheimer's disease Biological and medical sciences Chicago - epidemiology cognition Cognition & reasoning Cognition Disorders - epidemiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Educational Status European Continental Ancestry Group Female Fundamental and applied biological sciences. Psychology Geriatric psychiatry Geriatrics Humans Longitudinal Studies Male Medical sciences Middle Aged mortality Neurology Psychoanalysis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry race Regression analysis Survival analysis White people |
| title | Cognitive decline and survival in Alzheimer's disease |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T08%3A23%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cognitive%20decline%20and%20survival%20in%20Alzheimer's%20disease&rft.jtitle=International%20journal%20of%20geriatric%20psychiatry&rft.au=Wilson,%20Robert%20S.&rft.date=2006-04&rft.volume=21&rft.issue=4&rft.spage=356&rft.epage=362&rft.pages=356-362&rft.issn=0885-6230&rft.eissn=1099-1166&rft.coden=IJGPES&rft_id=info:doi/10.1002/gps.1472&rft_dat=%3Cproquest_cross%3E67827095%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4452-690d65af956ad287f6dc3ca19e8e2ec515ad43d3cada460c8842f1410262d8bb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=220517414&rft_id=info:pmid/16534773&rfr_iscdi=true |