Taurolidine lock: The key to prevention of recurrent catheter-related bloodstream infections

The literature shows that repeated courses of antibiotics and catheter removals in a subset of patients suffering from multiple catheter-related bloodstream infections (CRBSI), are unlikely to prevent recurrence. In acceding to preventative strategies, we report our application of the antimicrobial...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2005-06, Vol.24 (3), p.462-465
Main Authors: Jurewitsch, Brian, Jeejeebhoy, Khursheed N.
Format: Article
Language:English
Subjects:
Adult
Anti-Infective Agents, Local - administration & dosage
Bacteremia - prevention & control
Biological and medical sciences
Bloodstream infection
Catheter infection
Catheters, Indwelling - adverse effects
Catheters, Indwelling - microbiology
Humans
Lock solution
Medical sciences
Metabolic diseases
Middle Aged
Parenteral Nutrition, Home - adverse effects
Taurine - administration & dosage
Taurine - analogs & derivatives
Taurolidine
Thiadiazines - administration & dosage
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Summary:The literature shows that repeated courses of antibiotics and catheter removals in a subset of patients suffering from multiple catheter-related bloodstream infections (CRBSI), are unlikely to prevent recurrence. In acceding to preventative strategies, we report our application of the antimicrobial chemotherapeutic Taurolidine used as a daily flush solution in seven home TPN patients suffering from multiple episodes. A pretreatment infection rate of 10.8 infections per 1000 catheter days decreased to 0.8 after treatment.
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2005.02.001