Anti-complementary Activity of Ursane-Type Triterpenoids from Weigela subsessilis

A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new tr...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2006, Vol.29(4), pp.830-833
Main Authors: Thuong, Phuong Thien, Min, Byung-Sun, Jin, WenYi, Na, MinKyun, Lee, JongPill, Seong, RackSeon, Lee, Young-Mi, Song, KyungSik, Seong, YeonHee, Lee, Hyeong-Kyu, Bae, KiHwan, Kang, Sam Sik
Format: Article
Language:English
Subjects:
Animals
anti-complementary
Caprifoliaceae
Complement System Proteins - physiology
Erythrocytes - drug effects
Erythrocytes - metabolism
Plant Leaves - chemistry
Plant Stems - chemistry
Plants, Medicinal - chemistry
Sheep
Stereoisomerism
Structure-Activity Relationship
Triterpenes - pharmacology
ursane-type triterpenoid
Weigela subsessilis
weigelic acid
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Summary:A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was established as 1β,2α,3α,23-tetrahydroxyurs-12-en-28-oic acid on the basis of spectroscopic analyses. In addition, the isolated compounds were evaluated for their anti-complement activity against the classical pathway of the complement system. Of these, compounds 1—2 and 4—8 exhibited anti-complement activity with IC50 values of 152, 90, 130, 51, 56, 4, and 163 μM, respectively, whereas 3 was inactive. This shows that a carboxylic group of ursane-type triterpenoids seems to play an important role in inhibiting the hemolytic activity of human serum against erythrocytes.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.29.830