Decreased plasma antioxidants in patients with Alzheimer's disease

Objectives It has been suggested that oxidative injuries have an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we assess whether the plasma levels of albumin, bilirubin, and uric acid would be altered in the AD patients compared to those of the healthy controls....

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Bibliographic Details
Published in:International journal of geriatric psychiatry 2006-04, Vol.21 (4), p.344-348
Main Authors: Kim, Tae-Suk, Pae, Chi-Un, Yoon, Su-Jung, Jang, Woo-Young, Lee, Nam Jin, Kim, Jung-Jin, Lee, Soo-Jung, Lee, Chul, Paik, In-Ho, Lee, Chang-Uk
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - blood
Alzheimer's disease
Antioxidants
Bilirubin - blood
Biological and medical sciences
Biomarkers - blood
Clinical trials
Cognition & reasoning
Cognition Disorders - blood
cognitive function
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Fundamental and applied biological sciences. Psychology
Geriatric psychiatry
Geriatrics
Humans
Male
Medical sciences
Neurology
Pathology
Psychoanalysis
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Serum Albumin - analysis
Uric Acid - blood
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Summary:Objectives It has been suggested that oxidative injuries have an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we assess whether the plasma levels of albumin, bilirubin, and uric acid would be altered in the AD patients compared to those of the healthy controls. Furthermore, we tried to find the correlations between plasma antioxidant levels and the cognitive function in AD patients. Methods The plasma albumin, bilirubin, and uric acid levels were measured by standard methods in 101 AD patients and 101 healthy controls. The Korean version of the Mini Mental Status Examination (MMSE‐K) was used to evaluate the cognitive functions of AD patients. Results A significant reduction in the albumin, bilirubin, and uric acid levels in the AD group was found compared to those of the control group. The scores of MMSE‐K showed the positive correlation with albumin level in the AD group after adjusting confounding factors such as body mass index, gender and age. Conclusion This study showed that oxidative injuries could be involved in the pathogenesis of AD, as well as indicating that some antioxidant might be associated with the cognitive functions in AD. Copyright © 2006 John Wiley & Sons, Ltd.
ISSN:0885-6230
1099-1166
DOI:10.1002/gps.1469