Gene expression in mixed type liposarcoma

Mixed type liposarcomas are rare. Here, we analysed the characteristics of an unusual case of mixed type liposarcoma, which consisted of a well-differentiated liposarcoma (WDL) and a pleomorphic liposarcoma (PL), with a special emphasis on molecular alterations. Microscopic and immunohistochemical a...

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Bibliographic Details
Published in:Pathology 2006-04, Vol.38 (2), p.114-119
Main Authors: Il Kim, Jeung, Un Choi, Kyung, Sook Lee, In, Yong Moon, Tae, Hun Lee, Chang, Woong Kim, Hwal, Yeon Kim, Jee, Youn Park, Do, Young Sol, Mee
Format: Article
Language:English
Subjects:
Adipose Tissue - anatomy & histology
Adipose Tissue - chemistry
Aged
Biological and medical sciences
Biomarkers, Tumor - analysis
cDNA microarray
DNA, Neoplasm - analysis
gene expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Liposarcoma - genetics
Liposarcoma - pathology
Liposarcoma - surgery
Male
Medical sciences
Mixed type liposarcoma
Oligonucleotide Array Sequence Analysis
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Soft Tissue Neoplasms - genetics
Soft Tissue Neoplasms - pathology
Soft Tissue Neoplasms - surgery
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Summary:Mixed type liposarcomas are rare. Here, we analysed the characteristics of an unusual case of mixed type liposarcoma, which consisted of a well-differentiated liposarcoma (WDL) and a pleomorphic liposarcoma (PL), with a special emphasis on molecular alterations. Microscopic and immunohistochemical approaches were used to investigate this case of mixed type liposarcoma, and to identify molecular alterations in this tumour, gene expression was examined in PL, WDL, and normal adipose tissue (NA) samples using a 17000 cDNA microarray. The tumour mass, 9 × 5 × 5cm, was located in the left upper arm of a 76-year-old man. Grossly, the proximal portion of the tumour was composed of a yellowish fatty lesion, whereas the distal portion of the tumour was whitish and necrotic in nature. Histologically, the tumour was composed of two distinct components. The proximal component of the tumour was a WDL and the distal component was a PL. Immunohistochemically, S100 protein immunoreactivity highlighted lipoblasts in both tumour portions. The Ki-67 proliferation index was
ISSN:0031-3025
1465-3931
DOI:10.1080/00313020600557078