Gingival Crevicular Fluid Leptin Levels in Periodontitis Patients With Long‐Term and Heavy Smoking

• Published in: Journal of periodontology (1970) 2006-04, Vol.77 (4), p.634-640
• Main Authors: Bozkurt, F. Yeşim, Yetkin Ay, Z., Sütçü, R., Delibaş, N., Demirel, R.
• Format: Article
• Language: English
• Subjects: Adult; Case-Control Studies; Chronic Disease; Dentistry; Enzyme-Linked Immunosorbent Assay; Female; Gingival crevicular fluid; Gingival Crevicular Fluid - chemistry; Gingival Crevicular Fluid - metabolism; Humans; leptin; Leptin - analysis; Leptin - metabolism; Male; Periodontal Index; periodontitis; Periodontitis - immunology; Periodontitis - metabolism; smoking; Smoking - immunology; Smoking - metabolism; Statistics, Nonparametric
• ISSN: 0022-3492; 1943-3670
• DOI: 10.1902/jop.2006.050277

Background: The aim of the present study was to evaluate gingival crevicular fluid (GCF) leptin levels and the influence of long‐term and heavy smoking on GCF leptin levels in patients with chronic periodontitis. Methods: In this study, 143 individuals were divided into three groups: non‐smokers (NS), smokers (S), and control (C). Three subgroups of NS and S were grouped as follows: a) probing depth (PD) ≤3 mm; b) PD = 4 to 5 mm; and c) PD >5 mm. For each patient, PD, gingival index (GI), plaque index (PI), gingival bleeding time index (GBTI), and clinical attachment level (CAL) values were recorded. The GCF leptin levels obtained from sampling sites were determined by using enzyme‐linked immunosorbent assay kits. Results: The GCF leptin levels were found significantly lower in the a and b subgroups in the S group than those in the NS group (P