Effect of chronic Albizzia julibrissin treatment on 5-hydroxytryptamine1A receptors in rat brain

Quantitative receptor autoradiography and behavioral studies were employed to investigate whether the aqueous extract of Albizzia julibrissin (AEAJ) specifically targets serotonergic systems in rat brain. AEAJ was orally administered at 50 and 200 mg/kg to adult male SD rats for 7 days. Treatment wi...

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Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2005-05, Vol.81 (1), p.205-210
Main Authors: JI WOOK JUNG, CHO, Jae-Han, NAM YOON AHN, HYE RIM OH, SUN YEOU KIM, JANG, Choon-Gon, JONG HOON RYU
Format: Article
Language:English
Subjects:
Affectivity. Emotion
Albizzia
Animals
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Male
Maze Learning - drug effects
Maze Learning - physiology
Personality. Affectivity
Plant Bark
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Protein Binding - drug effects
Protein Binding - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Sprague-Dawley
Receptor, Serotonin, 5-HT1A - metabolism
Serotonin 5-HT1 Receptor Agonists
Serotonin 5-HT1 Receptor Antagonists
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Summary:Quantitative receptor autoradiography and behavioral studies were employed to investigate whether the aqueous extract of Albizzia julibrissin (AEAJ) specifically targets serotonergic systems in rat brain. AEAJ was orally administered at 50 and 200 mg/kg to adult male SD rats for 7 days. Treatment with AEAJ (200 mg/kg) significantly increased time-spent in open arms and the number of open arm entries in an elevated plus-maze (EPM) versus saline controls (P
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2005.03.014