Metabolism of daidzein by Nocardia species NRRL 5646 and Mortierella isabellina ATCC 38063

• Published in: Phytochemistry (Oxford) 2005-05, Vol.66 (9), p.1007-1011
• Main Authors: Maatooq, Galal T., Rosazza, John P.N.
• Format: Article
• Language: English
• Subjects: Animal and plant ecology; Animal, plant and microbial ecology; Autoecology; biochemical pathways; Biological and medical sciences; Biotransformation; Chemical constitution; chemical structure; Daidzein; daidzein-4'-rhamnopyranoside; Fundamental and applied biological sciences. Psychology; Hydroxylation; Isoflavone; Isoflavones - metabolism; Isoformononetin; metabolites; Methylation; Microbial metabolism; Models, Chemical; Molecular Structure; Morteirella isabellina; Mortierella; Mortierella - metabolism; Mortierella isabellina; Nocardia; Nocardia - metabolism; Nocardia species; Phytoestrogens - metabolism; Plant physiology and development; Plants and fungi; spectral analysis
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2005.03.013

The phytoestrogen daidzein was metabolized by Nocardia species NRRL 5646 to give two metabolites obtained by hydroxylation and methylation. These metabolites were spectrally characterized as 7-methoxy-4′-hydroxyisoflavone (isoformononetin) and 7,8-dimethoxy-4′-hydroxyisoflavone. Mortierella isabellina ATCC 38063 was able to metabolize daidzein to the unusual metabolite daidzein-4′-rhamnopyranoside The phytoestrogen daidzein was metabolized by Nocardia species NRRL 5646 to give two metabolites obtained by hydroxylation and methylation. These metabolites were spectrally characterized as 7-methoxy-4′-hydroxyisoflavone (isoformononetin) and 7,8-dimethoxy-4′-hydroxyisoflavone. Mortierella isabellina ATCC 38063 was able to metabolize daidzein to the unusual metabolite daidzein-4′-rhamnopyranoside.