Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues

Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2005-05 (20), p.2555-2557
Main Authors: Ranasinghe, Rohan T, Rusling, David A, Powers, Vicki E C, Fox, Keith R, Brown, Tom
Format: Article
Language:English
Subjects:
Base Pairing
Cytosine - analysis
Cytosine - chemistry
DNA - chemistry
Guanine - analysis
Guanine - chemistry
Hydrogen Bonding
Nucleic Acid Conformation
Nucleosides - chemical synthesis
Nucleosides - chemistry
Oligonucleotides - chemistry
Pyrimidinones - chemical synthesis
Pyrimidinones - chemistry
Thymine - analysis
Thymine - chemistry
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Description
Summary:Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.
ISSN:1359-7345
1364-548X
DOI:10.1039/b502325d