Cancer CXC chemokine networks and tumour angiogenesis

Chemokines have pleiotropic effects in regulating immunity, angiogenesis, stem cell trafficking, and mediating organ-specific metastases of cancer. In the context of angiogenesis, the CXC chemokine family is a unique group of cytokines known for their ability to behave in a disparate manner in the r...

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Bibliographic Details
Published in:European journal of cancer (1990) 2006-04, Vol.42 (6), p.768-778
Main Authors: Strieter, Robert M., Burdick, Marie D., Mestas, Javier, Gomperts, Brigitte, Keane, Michael P., Belperio, John A.
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenesis Inhibitors - immunology
Angiogenesis Inhibitors - physiology
Angiostasis
Angiostatic Proteins - immunology
Angiostatic Proteins - physiology
Biological and medical sciences
Cancer
Chemokines, CXC - physiology
CXC chemokines
Humans
Immunity, Cellular
Medical sciences
Neoplasms - blood supply
Neoplasms - immunology
Neoplasms - pathology
Neovascularization, Pathologic - etiology
Neovascularization, Pathologic - immunology
Neovascularization, Pathologic - pathology
Pharmacology. Drug treatments
Tumors
Tumourigenesis
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Summary:Chemokines have pleiotropic effects in regulating immunity, angiogenesis, stem cell trafficking, and mediating organ-specific metastases of cancer. In the context of angiogenesis, the CXC chemokine family is a unique group of cytokines known for their ability to behave in a disparate manner in the regulation of angiogenesis. The glutamic acid–leucine–arginine (ELR+) CXC chemokines are potent promoters of angiogenesis, and mediate their angiogenic activity via signal-coupling of CXCR2 on endothelium. By contrast, members of the CXC chemokine family, such as platelet factor-4 (PF4; CXCL4) and interferon-inducible CXC chemokines are potent inhibitors of angiogenesis, and use CXCR3 on endothelium to mediate their angiostatic activity. This review will discuss the biology of CXC chemokines in the context of angiogenesis related to cancer.
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2006.01.006