Dramatic increase in a single genotype of TRNG ciprofloxacin-resistant Neisseria gonorrhoeae isolates in men who have sex with men

In 2003, episodes of gonorrhoea caused by ciprofloxacin-resistant strains increased to 15.3% from 11% in 2002. This was coincident with a marked increase in strains characterized as serogroup WI, ciprofloxacin-resistant bearing the tetracycline resistance plasmid. Molecular typing of these strains,...

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Bibliographic Details
Published in:International journal of STD & AIDS 2006-04, Vol.17 (4), p.254-256
Main Authors: PALMER, H. M, YOUNG, H
Format: Article
Language:English
Subjects:
AIDS/HIV
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Bacterial diseases
Bacterial diseases of the genital system
Bacterial Typing Techniques
Biological and medical sciences
Ciprofloxacin - pharmacology
Ciprofloxacin - therapeutic use
Drug Resistance, Bacterial - genetics
England - epidemiology
Epidemiology. Vaccinations
General aspects
Genotype
Gonorrhea - drug therapy
Gonorrhea - epidemiology
Gonorrhea - etiology
Gonorrhea - microbiology
Gonorrhea - prevention & control
Homosexuality, Male
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Neisseria gonorrhoeae
Neisseria gonorrhoeae - drug effects
Neisseria gonorrhoeae - genetics
Neisseria gonorrhoeae - isolation & purification
Wales - epidemiology
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Summary:In 2003, episodes of gonorrhoea caused by ciprofloxacin-resistant strains increased to 15.3% from 11% in 2002. This was coincident with a marked increase in strains characterized as serogroup WI, ciprofloxacin-resistant bearing the tetracycline resistance plasmid. Molecular typing of these strains, using Neisseria gonorrhoeae multiantigen sequence typing (NG-MAST) revealed 71% (34/48) were of the same sequence type, ST338, accounting for 4.1% (34/824) of all strains in 2003. Epidemiological data demonstrated that transmission of ST338 was associated with men who have sex with men (MSM; 23/27), acquisition within the UK (22/26) and having two or more partners in the previous three-month period (18/27). The combined use of highly discriminatory typing and epidemiological surveillance helps to identify successful transmission networks.
ISSN:0956-4624
1758-1052
DOI:10.1258/095646206776253408