Trisomy 8 as the sole cytogenetic abnormality in a case of extraskeletal mesenchymal chondrosarcoma

Mesenchymal chondrosarcoma is a rare malignant tumor that comprises about 3–10% of all sarcomas. Reports of cytogenetic studies of mesenchymal chondrosarcoma are limited and no consistent cytogenetic abnormality has surfaced. Some mesenchymal chondrosarcomas have a t(11;22) translocation suggesting...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2005-06, Vol.159 (2), p.151-154
Main Authors: Gatter, Ken M., Olson, Susan, Lawce, Helen, Rader, Anne E.
Format: Article
Language:English
Subjects:
Child
Chondrosarcoma, Mesenchymal - genetics
Chromosomes, Human, Pair 8
Female
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Soft Tissue Neoplasms - genetics
Soft Tissue Neoplasms - pathology
Thigh
Trisomy
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Summary:Mesenchymal chondrosarcoma is a rare malignant tumor that comprises about 3–10% of all sarcomas. Reports of cytogenetic studies of mesenchymal chondrosarcoma are limited and no consistent cytogenetic abnormality has surfaced. Some mesenchymal chondrosarcomas have a t(11;22) translocation suggesting a relationship with the PNET/Ewing tumor family. We report what to our knowledge is the first case of trisomy 8 as the sole cytogenetic abnormality in a mesenchymal chondrosarcoma.
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2004.10.007