Spermatogonial stem cells: questions, models and perspectives

This review looks into the phylogeny of spermatogonial stem cells and describes their basic biological features. We are focusing on species-specific differences of spermatogonial stem cell physiology. We propose revised models for the clonal expansion of spermatogonia and for the potential existence...

Full description

Saved in:
Bibliographic Details
Published in:Human reproduction update 2006-05, Vol.12 (3), p.275-282
Main Authors: Ehmcke, Jens, Wistuba, Joachim, Schlatt, Stefan
Format: Article
Language:English
Subjects:
Animals
Biological Evolution
Clone Cells - classification
Clone Cells - cytology
Clone Cells - physiology
germ cell transplantation
Humans
Male
Models, Biological
phylogeny
Pluripotent Stem Cells - classification
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - physiology
Primates
Rats
species-specific differences
Spermatogonia - classification
Spermatogonia - cytology
Spermatogonia - physiology
spermatogonial stem cells
Stem Cell Transplantation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c426t-2868fa2f25831da5ff66626ddd2dbafa69a134d3dd78cec9c53fbc8518a723023
cites cdi_FETCH-LOGICAL-c426t-2868fa2f25831da5ff66626ddd2dbafa69a134d3dd78cec9c53fbc8518a723023
container_end_page 282
container_issue 3
container_start_page 275
container_title Human reproduction update
container_volume 12
creator Ehmcke, Jens
Wistuba, Joachim
Schlatt, Stefan
description This review looks into the phylogeny of spermatogonial stem cells and describes their basic biological features. We are focusing on species-specific differences of spermatogonial stem cell physiology. We propose revised models for the clonal expansion of spermatogonia and for the potential existence of true stem cells and progenitors in primates but not in rodents. We create a new model for the species-specific arrangements of spermatogenic stages which may depend on the variable clonal expansion patterns. We also provide a brief overview of germ cell transplantation as a powerful tool for basic research and its potential use in a clinical setting.
doi_str_mv 10.1093/humupd/dmk001
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67840699</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1020697611</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-2868fa2f25831da5ff66626ddd2dbafa69a134d3dd78cec9c53fbc8518a723023</originalsourceid><addsrcrecordid>eNqF0M1LwzAYBvAgipvTo1cpHjxZ13w0TQQPsqkTBRl-skvImlS7NU1tWtH_3swNB1485YX8eHjfB4B9GJ3AiOP-W2vaSvWVmUcR3ABdSGgUIkz5pp9xHIckYbQDdpybeUAhS7ZBB1JCKIa8C87uK10b2dhXW-ayCFyjTZDqonCnwXurXZPb0h0HxipduECWKvDeVTpt8g_tdsFWJgun91ZvDzxeXjwMRuHt3dX14Pw2TAmiTYgYZZlEGYoZhkrGWUYpRVQphdRUZpJyCTFRWKmEpTrlaYyzacpiyGSCcIRwDxwtc6va_mwlTO4WW8pS29YJmjASUc7_hZBznxgnHh7-gTPb1qU_QiAIF4wTj8IlSmvrXK0zUdW5kfWXgJFYtC-W7Ytl-94frELbqdFqrVd1rwNz3_Pn77-s5_4EnMRi9DIRk-H4afw8vBED_A3edJG7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211199794</pqid></control><display><type>article</type><title>Spermatogonial stem cells: questions, models and perspectives</title><source>Oxford Journals Online</source><creator>Ehmcke, Jens ; Wistuba, Joachim ; Schlatt, Stefan</creator><creatorcontrib>Ehmcke, Jens ; Wistuba, Joachim ; Schlatt, Stefan</creatorcontrib><description>This review looks into the phylogeny of spermatogonial stem cells and describes their basic biological features. We are focusing on species-specific differences of spermatogonial stem cell physiology. We propose revised models for the clonal expansion of spermatogonia and for the potential existence of true stem cells and progenitors in primates but not in rodents. We create a new model for the species-specific arrangements of spermatogenic stages which may depend on the variable clonal expansion patterns. We also provide a brief overview of germ cell transplantation as a powerful tool for basic research and its potential use in a clinical setting.</description><identifier>ISSN: 1355-4786</identifier><identifier>EISSN: 1460-2369</identifier><identifier>DOI: 10.1093/humupd/dmk001</identifier><identifier>PMID: 16446319</identifier><identifier>CODEN: HRUPF8</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Biological Evolution ; Clone Cells - classification ; Clone Cells - cytology ; Clone Cells - physiology ; germ cell transplantation ; Humans ; Male ; Models, Biological ; phylogeny ; Pluripotent Stem Cells - classification ; Pluripotent Stem Cells - cytology ; Pluripotent Stem Cells - physiology ; Primates ; Rats ; species-specific differences ; Spermatogonia - classification ; Spermatogonia - cytology ; Spermatogonia - physiology ; spermatogonial stem cells ; Stem Cell Transplantation</subject><ispartof>Human reproduction update, 2006-05, Vol.12 (3), p.275-282</ispartof><rights>Copyright Oxford University Press(England) May 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-2868fa2f25831da5ff66626ddd2dbafa69a134d3dd78cec9c53fbc8518a723023</citedby><cites>FETCH-LOGICAL-c426t-2868fa2f25831da5ff66626ddd2dbafa69a134d3dd78cec9c53fbc8518a723023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16446319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ehmcke, Jens</creatorcontrib><creatorcontrib>Wistuba, Joachim</creatorcontrib><creatorcontrib>Schlatt, Stefan</creatorcontrib><title>Spermatogonial stem cells: questions, models and perspectives</title><title>Human reproduction update</title><addtitle>Hum. Reprod. Update</addtitle><description>This review looks into the phylogeny of spermatogonial stem cells and describes their basic biological features. We are focusing on species-specific differences of spermatogonial stem cell physiology. We propose revised models for the clonal expansion of spermatogonia and for the potential existence of true stem cells and progenitors in primates but not in rodents. We create a new model for the species-specific arrangements of spermatogenic stages which may depend on the variable clonal expansion patterns. We also provide a brief overview of germ cell transplantation as a powerful tool for basic research and its potential use in a clinical setting.</description><subject>Animals</subject><subject>Biological Evolution</subject><subject>Clone Cells - classification</subject><subject>Clone Cells - cytology</subject><subject>Clone Cells - physiology</subject><subject>germ cell transplantation</subject><subject>Humans</subject><subject>Male</subject><subject>Models, Biological</subject><subject>phylogeny</subject><subject>Pluripotent Stem Cells - classification</subject><subject>Pluripotent Stem Cells - cytology</subject><subject>Pluripotent Stem Cells - physiology</subject><subject>Primates</subject><subject>Rats</subject><subject>species-specific differences</subject><subject>Spermatogonia - classification</subject><subject>Spermatogonia - cytology</subject><subject>Spermatogonia - physiology</subject><subject>spermatogonial stem cells</subject><subject>Stem Cell Transplantation</subject><issn>1355-4786</issn><issn>1460-2369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqF0M1LwzAYBvAgipvTo1cpHjxZ13w0TQQPsqkTBRl-skvImlS7NU1tWtH_3swNB1485YX8eHjfB4B9GJ3AiOP-W2vaSvWVmUcR3ABdSGgUIkz5pp9xHIckYbQDdpybeUAhS7ZBB1JCKIa8C87uK10b2dhXW-ayCFyjTZDqonCnwXurXZPb0h0HxipduECWKvDeVTpt8g_tdsFWJgun91ZvDzxeXjwMRuHt3dX14Pw2TAmiTYgYZZlEGYoZhkrGWUYpRVQphdRUZpJyCTFRWKmEpTrlaYyzacpiyGSCcIRwDxwtc6va_mwlTO4WW8pS29YJmjASUc7_hZBznxgnHh7-gTPb1qU_QiAIF4wTj8IlSmvrXK0zUdW5kfWXgJFYtC-W7Ytl-94frELbqdFqrVd1rwNz3_Pn77-s5_4EnMRi9DIRk-H4afw8vBED_A3edJG7</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Ehmcke, Jens</creator><creator>Wistuba, Joachim</creator><creator>Schlatt, Stefan</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Spermatogonial stem cells: questions, models and perspectives</title><author>Ehmcke, Jens ; Wistuba, Joachim ; Schlatt, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-2868fa2f25831da5ff66626ddd2dbafa69a134d3dd78cec9c53fbc8518a723023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biological Evolution</topic><topic>Clone Cells - classification</topic><topic>Clone Cells - cytology</topic><topic>Clone Cells - physiology</topic><topic>germ cell transplantation</topic><topic>Humans</topic><topic>Male</topic><topic>Models, Biological</topic><topic>phylogeny</topic><topic>Pluripotent Stem Cells - classification</topic><topic>Pluripotent Stem Cells - cytology</topic><topic>Pluripotent Stem Cells - physiology</topic><topic>Primates</topic><topic>Rats</topic><topic>species-specific differences</topic><topic>Spermatogonia - classification</topic><topic>Spermatogonia - cytology</topic><topic>Spermatogonia - physiology</topic><topic>spermatogonial stem cells</topic><topic>Stem Cell Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ehmcke, Jens</creatorcontrib><creatorcontrib>Wistuba, Joachim</creatorcontrib><creatorcontrib>Schlatt, Stefan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction update</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ehmcke, Jens</au><au>Wistuba, Joachim</au><au>Schlatt, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spermatogonial stem cells: questions, models and perspectives</atitle><jtitle>Human reproduction update</jtitle><addtitle>Hum. Reprod. Update</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>12</volume><issue>3</issue><spage>275</spage><epage>282</epage><pages>275-282</pages><issn>1355-4786</issn><eissn>1460-2369</eissn><coden>HRUPF8</coden><abstract>This review looks into the phylogeny of spermatogonial stem cells and describes their basic biological features. We are focusing on species-specific differences of spermatogonial stem cell physiology. We propose revised models for the clonal expansion of spermatogonia and for the potential existence of true stem cells and progenitors in primates but not in rodents. We create a new model for the species-specific arrangements of spermatogenic stages which may depend on the variable clonal expansion patterns. We also provide a brief overview of germ cell transplantation as a powerful tool for basic research and its potential use in a clinical setting.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>16446319</pmid><doi>10.1093/humupd/dmk001</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1355-4786
ispartof Human reproduction update, 2006-05, Vol.12 (3), p.275-282
issn 1355-4786
1460-2369
language eng
recordid cdi_proquest_miscellaneous_67840699
source Oxford Journals Online
subjects Animals
Biological Evolution
Clone Cells - classification
Clone Cells - cytology
Clone Cells - physiology
germ cell transplantation
Humans
Male
Models, Biological
phylogeny
Pluripotent Stem Cells - classification
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - physiology
Primates
Rats
species-specific differences
Spermatogonia - classification
Spermatogonia - cytology
Spermatogonia - physiology
spermatogonial stem cells
Stem Cell Transplantation
title Spermatogonial stem cells: questions, models and perspectives
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T07%3A57%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Spermatogonial%20stem%20cells:%20questions,%20models%20and%20perspectives&rft.jtitle=Human%20reproduction%20update&rft.au=Ehmcke,%20Jens&rft.date=2006-05-01&rft.volume=12&rft.issue=3&rft.spage=275&rft.epage=282&rft.pages=275-282&rft.issn=1355-4786&rft.eissn=1460-2369&rft.coden=HRUPF8&rft_id=info:doi/10.1093/humupd/dmk001&rft_dat=%3Cproquest_cross%3E1020697611%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c426t-2868fa2f25831da5ff66626ddd2dbafa69a134d3dd78cec9c53fbc8518a723023%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=211199794&rft_id=info:pmid/16446319&rfr_iscdi=true