The mammalian Mediator complex and its role in transcriptional regulation

Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2005-05, Vol.30 (5), p.250-255
Main Authors: Conaway, Ronald C., Sato, Shigeo, Tomomori-Sato, Chieri, Yao, Tingting, Conaway, Joan W.
Format: Article
Language:English
Subjects:
Animals
Gene Expression Regulation
Multiprotein Complexes
Protein Subunits - genetics
Protein Subunits - metabolism
RNA Polymerase II - metabolism
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Transcription Factors - metabolism
Transcription, Genetic
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Summary:Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2005.03.002