Effects of the Nitric Oxide Donor Nitroprusside on No-Reflow Phenomenon During Coronary Interventions for Acute Myocardial Infarction

We tested the effects of the nitric oxide donor nitroprusside as treatment for no reflow in 23 consecutive patients who underwent coronary angioplasty for acute myocardial infarction. No reflow was defined as a decrease of ≥1 Thrombolysis In Myocardial Infarction (TIMI) trial flow grade occurring af...

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Bibliographic Details
Published in:The American journal of cardiology 2005-06, Vol.95 (11), p.1358-1361
Main Authors: Pasceri, Vincenzo, Pristipino, Christian, Pelliccia, Francesco, Granatelli, Antonino, Speciale, Giulio, Roncella, Adriana, Pironi, Bruno, Capasso, Michele, Richichi, Giuseppe
Format: Article
Language:English
Subjects:
Angioplasty
Angioplasty, Balloon, Coronary
Biological and medical sciences
Cardiology. Vascular system
Coronary Circulation - drug effects
Coronary heart disease
Drug therapy
Female
Heart
Heart attacks
Humans
Male
Medical sciences
Middle Aged
Myocardial Infarction - physiopathology
Myocardial Infarction - therapy
Myocarditis. Cardiomyopathies
Nitric oxide
Nitric Oxide Donors - therapeutic use
Nitroprusside - therapeutic use
Prospective Studies
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Summary:We tested the effects of the nitric oxide donor nitroprusside as treatment for no reflow in 23 consecutive patients who underwent coronary angioplasty for acute myocardial infarction. No reflow was defined as a decrease of ≥1 Thrombolysis In Myocardial Infarction (TIMI) trial flow grade occurring after successful initial coronary recanalization. Nitroprusside induced a significant improvement in coronary flow, with an increase in TIMI flow grade from 1.5 ± 0.8 to 2.9 ± 0.3 (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.01.082