Renin-Angiotensin System Polymorphisms and Coronary Artery Surgery Patients

The frequencies of angiotensin-converting enzyme gene insertion/deletion, angiotensinogen-M253T, and angiotensin II type 1 receptor-A1166C polymorphisms were analyzed in 105 patients undergoing coronary artery bypass grafting (group 1) and a control group of 105 non-cardiac patients (group 2). Blood...

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Bibliographic Details
Published in:Asian cardiovascular & thoracic annals 2005-06, Vol.13 (2), p.153-156
Main Authors: Ozisik, Kanat, Misirlioglu, Muge, Ulus, Tulga A, Tuncer, Serdar, Emir, Mustafa, Katircioglu, Fehmi
Format: Article
Language:English
Subjects:
Aged
Angiotensinogen - genetics
Coronary Artery Bypass
Coronary Disease - genetics
Coronary Disease - surgery
DNA Transposable Elements
Female
Gene Deletion
Gene Frequency
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
Receptor, Angiotensin, Type 1 - genetics
Renin-Angiotensin System - genetics
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Summary:The frequencies of angiotensin-converting enzyme gene insertion/deletion, angiotensinogen-M253T, and angiotensin II type 1 receptor-A1166C polymorphisms were analyzed in 105 patients undergoing coronary artery bypass grafting (group 1) and a control group of 105 non-cardiac patients (group 2). Blood samples were obtained for biochemical analyses and DNA extraction. Genotyping was performed by polymerase-chain-reaction-based restriction analysis. According to the angiotensin-converting enzyme gene insertion/deletion polymorphism, 36.3% of patients in group 1 and 30.7% in group 2 were homozygous for the DD allele. This difference was not statistically significant. Angiotensin II type 1 receptor-A1166C genotype polymorphism was also not significantly different between the groups. The results showed the angiotensinogen-M235T polymorphism to be heterogenous. The MM homozygote frequency was significantly higher in controls (72.3%), whereas 80% of the TT homozygote frequency was in the surgical group (p = 0.001). These results show that although there were no significant differences in angiotensin-converting enzyme gene insertion/deletion and angiotensin II type 1 receptor-A1166C genotype polymorphisms between the groups, angiotensinogen-M235T polymorphism of TT homozygote frequency was significantly associated with patients undergoing coronary artery bypass surgery.
ISSN:0218-4923
1816-5370
DOI:10.1177/021849230501300212