Evidence that DNA damage detection machinery participates in DNA repair

The toroidal Rad9-Rad1-Hus1 checkpoint complex (9-1-1) is structurally similar to the proliferating cell nuclear antigen (PCNA), which serves as a sliding clamp platform for DNA replication and repair. 9-1-1 has been characterized as a sensor of DNA damage that functions in concert with the checkpoi...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2005-04, Vol.4 (4), p.529-532
Main Authors: Helt, Christopher E, Wang, Wensheng, Keng, Peter C, Bambara, Robert A
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cell Cycle
Cell Cycle Proteins - chemistry
Cell Cycle Proteins - physiology
DNA Damage
DNA Glycosylases - metabolism
DNA Polymerase beta - metabolism
DNA Repair
Exonucleases - physiology
Flap Endonucleases - metabolism
Gene Expression Regulation
Humans
Proliferating Cell Nuclear Antigen - metabolism
Protein Binding
Schizosaccharomyces
Schizosaccharomyces pombe Proteins - physiology
Transcription, Genetic
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Summary:The toroidal Rad9-Rad1-Hus1 checkpoint complex (9-1-1) is structurally similar to the proliferating cell nuclear antigen (PCNA), which serves as a sliding clamp platform for DNA replication and repair. 9-1-1 has been characterized as a sensor of DNA damage that functions in concert with the checkpoint control proteins ATM and ATR. However, recent data suggest that the 9-1-1 complex and its individual Rad9 component serve different and multiple functions in cells by sensing DNA damage, stimulating apoptosis, and regulating gene transcription. Recently it was reported that 9-1-1 interacts with and/or stimulates components of the base excision repair (BER) pathway including the S. pombe MutY homolog (MYH), human polymerase beta (Polbeta), and flap endonuclease 1 (FEN1). Furthermore, preliminary results indicate a stimulation of DNA ligase I. In this review, the likely direct participation of 9-1-1 in DNA repair is discussed.
ISSN:1551-4005
DOI:10.4161/cc.4.4.1598