Metabolic Profiling of Plasma from Discordant Schizophrenia Twins:  Correlation between Lipid Signals and Global Functioning in Female Schizophrenia Patients

1H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8 pairs of age-matched healthy twins in an effort to disentangle genetic and epigenetic components of schizophrenia. We identified alterations...

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Bibliographic Details
Published in:Journal of proteome research 2006-04, Vol.5 (4), p.756-760
Main Authors: Tsang, Tsz M, Huang, Jeffrey T.-J, Holmes, Elaine, Bahn, Sabine
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Case-Control Studies
Diseases in Twins - metabolism
Female
Humans
Interviews as Topic
Leukapheresis
Lipid Metabolism
Lipoproteins, LDL - blood
Lipoproteins, VLDL - blood
Nuclear Magnetic Resonance, Biomolecular
Schizophrenia - genetics
Schizophrenia - metabolism
Twin Studies as Topic
Twins, Monozygotic - metabolism
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Summary:1H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8 pairs of age-matched healthy twins in an effort to disentangle genetic and epigenetic components of schizophrenia. We identified alterations in the lipid profile of both affected and unaffected schizophrenia twins. Additionally, there is a close association of VLDL/LDL signals and Global Functioning Scores in female twins suffering from schizophrenia. Our results further support a link between metabolic disturbances and the etiopathology of schizophrenia. Keywords: schizophrenia • lipid • LDL • VLDL • global functioning score • metabolic profiling
ISSN:1535-3893
1535-3907
DOI:10.1021/pr0503782