Intracellular redox state regulation by parthenolide

In the present paper, we report a strong intracellular antioxidant activity of the sesquiterpene lactone parthenolide in the hippocampal HT22 cells. This effect is mediated by an increase of total glutathione at both, low (5 μM) and high (10 μM), concentrations. Parthenolide also increases the activ...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2005-07, Vol.332 (2), p.321-325
Main Authors: Herrera, Federico, Martin, Vanesa, Rodriguez-Blanco, Jezabel, García-Santos, Guillermo, Antolín, Isaac, Rodriguez, Carmen
Format: Article
Language:English
Subjects:
Animals
Antioxidant
Antioxidant/electrophile response element
Antioxidants - administration & dosage
Apoptosis - drug effects
Apoptosis - physiology
Cell Line
Cell Proliferation - drug effects
Dose-Response Relationship, Drug
Glutathione
Glutathione - metabolism
Hippocampus - cytology
Hippocampus - drug effects
Hippocampus - metabolism
Homeostasis - drug effects
Homeostasis - physiology
HT22 cells
Intracellular Fluid - metabolism
Mice
Neurons - cytology
Neurons - drug effects
Neurons - metabolism
Oxidation-Reduction - drug effects
Parthenolide
Sesquiterpenes - administration & dosage
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Summary:In the present paper, we report a strong intracellular antioxidant activity of the sesquiterpene lactone parthenolide in the hippocampal HT22 cells. This effect is mediated by an increase of total glutathione at both, low (5 μM) and high (10 μM), concentrations. Parthenolide also increases the activation of the antioxidant/electrophile response element. This effect is the possible mediator of glutathione increase, since the limiting enzyme on its synthesis possesses this response element on its promoter. Finally, we demonstrate that its antioxidant properties do not mediate its antiproliferative effect nor its inhibition of NF-κB.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2005.04.131