The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV)

A commercial plant extract derived from olive tree leaf ( Olea europaea) (LExt) and its major compound, oleuropein (Ole), inhibited the in vitro infectivity of the viral haemorrhagic septicaemia virus (VHSV), a salmonid rhabdovirus. Incubation of virus with LExt or Ole before infection reduced the v...

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Bibliographic Details
Published in:Antiviral research 2005-06, Vol.66 (2), p.129-136
Main Authors: Micol, Vicente, Caturla, Nuria, Pérez-Fons, Laura, Más, Vicente, Pérez, Luis, Estepa, Amparo
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral
Antiviral agents
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Biological and medical sciences
Cell Line
Medical sciences
Microbial Sensitivity Tests
Novirhabdovirus - drug effects
Novirhabdovirus - physiology
Olea
Olea - chemistry
Olea europaea
Oleuropein
Olive leaf extract
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plant Leaves - chemistry
Rhabdovirus
Salmonidae
VHSV
Viral hemorrhagic septicemia virus
Viral membrane fusion
Virus Replication - drug effects
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Summary:A commercial plant extract derived from olive tree leaf ( Olea europaea) (LExt) and its major compound, oleuropein (Ole), inhibited the in vitro infectivity of the viral haemorrhagic septicaemia virus (VHSV), a salmonid rhabdovirus. Incubation of virus with LExt or Ole before infection reduced the viral infectivity to 10 and 30%, respectively. Furthermore, LExt drastically decreased VHSV titers and viral protein accumulation (virucidal effect) in a dose dependent manner when added to cell monolayers 36 h post-infection. On the other hand, both the LExt and Ole were able to inhibit cell-to-cell membrane fusion induced by VHSV in uninfected cells, suggesting interactions with viral envelope. Therefore, we propose that O. europaea could be used as a potential source of promising natural antivirals, which have demonstrated to lack impact on health and environment. In addition, Ole could be used to design other related antiviral agents.
ISSN:0166-3542
1872-9096
DOI:10.1016/j.antiviral.2005.02.005