Central pontine and extrapontine myelinolysis: report of a case with a tragic outcome

To report a pediatric case of central pontine and extrapontine myelinolysis, a rare neurological disease often associated with rapid correction of hyponatremia. A 15 year-old female adolescent developed locked-in syndrome during severe hyponatremia. Brain magnetic resonance imaging was consistent wi...

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Bibliographic Details
Published in:Jornal de pediatria 2006-03, Vol.82 (2), p.157-160
Main Authors: Brito, Adriana Rocha, Vasconcelos, Marcio Moacyr, Cruz Júnior, Luiz Celso Hygino da, Oliveira, Maria Emília D C Q de, Azevedo, Adriana Rodrigues Miguel de, Rocha, Luciana Graça Vieira, Mendonça, Priscilla Costa
Format: Article
Language:English
Subjects:
Adolescent
Brain - pathology
Fatal Outcome
Female
Humans
Hyponatremia - diagnosis
Hyponatremia - etiology
Hyponatremia - therapy
Magnetic Resonance Imaging
Myelinolysis, Central Pontine - diagnosis
Myelinolysis, Central Pontine - etiology
Sodium - blood
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Summary:To report a pediatric case of central pontine and extrapontine myelinolysis, a rare neurological disease often associated with rapid correction of hyponatremia. A 15 year-old female adolescent developed locked-in syndrome during severe hyponatremia. Brain magnetic resonance imaging was consistent with the diagnosis of central pontine and extrapontine myelinolysis. Serum sodium correction should proceed slowly and cautiously, based upon a careful calculation of sodium deficit, in order to minimize metabolic stress and avoid the occurrence of this dreadful complication, which has a tragic outcome in most cases. There is no scientifically proved effective treatment for myelinolysis, and severe cases usually have a dismal prognosis.
ISSN:0021-7557
DOI:10.2223/JPED.1464