Results of assisted reproductive technique in men with cystic fibrosis

BACKGROUND: Sterility in men with cystic fibrosis (CF) raises the question of the use of assisted reproductive techniques (ART). A multidisciplinary network including adult CF centre and reproductive medicine units was set up to answer requests for ART. METHODS: This retrospective study included 25...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2006-05, Vol.21 (5), p.1232-1236
Main Authors: Hubert, Dominique, Patrat, Catherine, Guibert, Juliette, Thiounn, Nicolas, Bienvenu, Thierry, Viot, Géraldine, Jouannet, Pierre, Epelboin, Sylvie
Format: Article
Language:English
Subjects:
assisted reproductive techniques
Biological and medical sciences
cystic fibrosis
Cystic Fibrosis - complications
ethical issues
Female
Gynecology. Andrology. Obstetrics
Humans
ICSI
Infertility, Male - etiology
Insemination, Artificial
Male
Medical sciences
Pregnancy
Pregnancy Outcome
Sperm Injections, Intracytoplasmic
Spermatozoa - cytology
Spermatozoa - transplantation
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Summary:BACKGROUND: Sterility in men with cystic fibrosis (CF) raises the question of the use of assisted reproductive techniques (ART). A multidisciplinary network including adult CF centre and reproductive medicine units was set up to answer requests for ART. METHODS: This retrospective study included 25 men with CF between 1994 and 2004. Clinical status, semen analysis, CF mutations analysis and artificial insemination by donor (AID) or ICSI after surgical retrieval of sperm were monitored. RESULTS: All CF men had azoospermia. Two chose AID first (one delivery); 23 chose ICSI. Sperm were surgically retrieved in 21 cases, and ICSI was performed in 19. Pregnancies occurred in 12 of these 19 couples (63%) (two ectopic pregnancies, two spontaneous abortions, one termination of pregnancy for polymalformed twins and 11 single deliveries in nine couples). Two couples tried AID after ICSI failed; one had twins. Another adopted a child, and two had a spontaneous pregnancy. After a follow-up of 4.1±2.3 years, two patients died, two underwent lung transplantation and 21 remained stable. CONCLUSION: ART can help men with CF to become a father, but their health status and short survival need careful counselling and multidisciplinary medical care.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/dei453