Effect of first-trimester serum from pregnant women with high-resistance uterine artery Doppler resistance on extravillous trophoblast invasion

BACKGROUND: Abnormal uterine artery Doppler indices are associated with pregnancy complications such as pre-eclampsia and intrauterine growth restriction. Poor trophoblast invasion may be a consequence of, or be associated with, abnormal Doppler indices. OBJECTIVE: To evaluate in vitro trophoblast f...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2006-05, Vol.21 (5), p.1295-1298
Main Authors: Ganapathy, R., Ayling, L.J., Whitley, G.S.J., Cartwright, J.E., Thilaganathan, B.
Format: Article
Language:English
Subjects:
Adult
Arteries - diagnostic imaging
Biological and medical sciences
Cell Line
Cell Movement
Chorionic Villi - growth & development
Doppler
Female
Fetal Growth Retardation - blood
Fetal Growth Retardation - diagnostic imaging
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Pre-Eclampsia - blood
Pre-Eclampsia - diagnostic imaging
Pregnancy
pregnancy serum
Pregnancy Trimester, First - blood
Serum
trophoblast invasion
Trophoblasts - cytology
Trophoblasts - physiology
Ultrasonography, Doppler
uterine artery resistance
Uterus - blood supply
Uterus - diagnostic imaging
Vascular Resistance
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Summary:BACKGROUND: Abnormal uterine artery Doppler indices are associated with pregnancy complications such as pre-eclampsia and intrauterine growth restriction. Poor trophoblast invasion may be a consequence of, or be associated with, abnormal Doppler indices. OBJECTIVE: To evaluate in vitro trophoblast function following exposure to first-trimester serum from pregnancies with high uterine artery Doppler resistance indices. METHODS: Doppler ultrasound examination of the maternal uterine arteries was performed on women at 10–14 weeks’ gestation. Serum was collected from women with bilateral uterine artery notches with resistance indices above the 95th centile and from patients with normal uterine artery indices. The effect of serum on trophoblast invasion was determined using an established in vitro model from the extravillous trophoblast-derived cell line SGHPL-4. RESULTS: Trophoblastic invasion was significantly reduced when treated with serum from women with high-resistance compared with normal-resistance uterine artery Doppler indices (P < 0.05). CONCLUSION: Maternal serum in the first trimester of pregnancy from patients with high-resistance uterine artery Doppler indices appears to inhibit trophoblast invasion. This experimental model allows further investigation of factors responsible and the evaluation of therapeutic strategies.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/dei482