Amelioration of dural granulation tissue growth for primate neurophysiology

Four methods were tried in order to reduce the growth of granulation tissue on the dura. The best results were obtained using white petrolatum jelly, which almost completely suppressed the growth of granulation tissue when the recording chamber was filled with petrolatum. Collagen and acrylic seals...

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Bibliographic Details
Published in:Journal of neuroscience methods 2005-06, Vol.144 (2), p.203-205
Main Authors: Wilson, Fraser A.W., Ryou, Jae-Wook, Kim, Byoung-Hoon, Greenberg, Paul A.
Format: Article
Language:English
Subjects:
Acrylic Resins - therapeutic use
Animals
Brain - physiology
Collagen - pharmacology
Collagen - therapeutic use
Dura herniation
Dura Mater - injuries
Dura Mater - pathology
Dura Mater - surgery
Electrodes, Implanted - adverse effects
Electrophysiology - instrumentation
Electrophysiology - methods
Granulation tissue
Granulation Tissue - drug effects
Granulation Tissue - pathology
Granulation Tissue - physiopathology
Haplorhini - anatomy & histology
Haplorhini - physiology
Haplorhini - surgery
Hippocampus
Monkey
Neuron
Neurosurgical Procedures - adverse effects
Neurosurgical Procedures - methods
Petrolatum
Petrolatum - pharmacology
Petrolatum - therapeutic use
Prefrontal cortex
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Summary:Four methods were tried in order to reduce the growth of granulation tissue on the dura. The best results were obtained using white petrolatum jelly, which almost completely suppressed the growth of granulation tissue when the recording chamber was filled with petrolatum. Collagen and acrylic seals were very effective in one monkey. Panalog ointment slowed the growth of granulation tissue; preformed silicon sheets had no apparent effect. We conclude that long-term application of petrolatum jelly has no adverse effects and achieves striking suppression of the growth of granulation tissue.
ISSN:0165-0270
1872-678X
DOI:10.1016/j.jneumeth.2004.11.009