SUR, ABC proteins targeted by KATP channel openers

The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2005-06, Vol.38 (6), p.951-963
Main Authors: Moreau, Christophe, Prost, Anne-Lise, Dérand, Renaud, Vivaudou, Michel
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - chemistry
Animals
ATP-Binding Cassette Transporters - chemistry
ATP-Binding Cassette Transporters - metabolism
ATP-Binding Cassette Transporters - physiology
Cromakalim - pharmacology
Cytoplasm - metabolism
Diazoxide - pharmacology
Down-Regulation
Humans
KATP Channels
Models, Biological
Pinacidil - pharmacology
Potassium Channels - chemistry
Potassium Channels - physiology
Potassium Channels, Inwardly Rectifying - chemistry
Potassium Channels, Inwardly Rectifying - metabolism
Potassium Channels, Inwardly Rectifying - physiology
Protein Binding
Protein Isoforms
Protein Structure, Secondary
Protein Structure, Tertiary
Receptors, Drug - chemistry
Receptors, Drug - physiology
Sulfonylurea Receptors
Up-Regulation
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Summary:The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex SUR serves as a regulatory subunit which fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity. We here review current knowledge on the molecular basis of the interaction of classical K(ATP) channel openers (cromakalim, pinacidil, diazoxide) with SUR.
ISSN:0022-2828
DOI:10.1016/j.yjmcc.2004.11.030