REM sleep behavior disorder, hallucinations, and cognitive impairment in Parkinson's disease

The objective of this study was to evaluate the relationship between REM sleep behavior disorder (RBD), hallucinations, and cognitive impairment in Parkinson's disease (PD). One hundred and ten PD patients, divided into three groups (without RBD or hallucinations; with RBD but no hallucinations...

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Bibliographic Details
Published in:Movement disorders 2006-04, Vol.21 (4), p.462-466
Main Authors: Sinforiani, Elena, Zangaglia, Roberta, Manni, Raffaele, Cristina, Silvano, Marchioni, Enrico, Nappi, Giuseppe, Mancini, Francesca, Pacchetti, Claudio
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cognition Disorders - complications
cognitive impairment
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Female
hallucinations
Hallucinations - complications
Humans
Male
Medical sciences
Mental Status Schedule
Middle Aged
Multivariate Analysis
Nervous system (semeiology, syndromes)
Neurology
Neuropsychological Tests
Parkinson Disease - complications
Parkinson's disease
REM sleep behavior disorder
REM Sleep Behavior Disorder - complications
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Summary:The objective of this study was to evaluate the relationship between REM sleep behavior disorder (RBD), hallucinations, and cognitive impairment in Parkinson's disease (PD). One hundred and ten PD patients, divided into three groups (without RBD or hallucinations; with RBD but no hallucinations; with RBD and hallucinations), were submitted to neuropsychological evaluation. The group without RBD and hallucinations showed normal neuropsychological tests when compared to normal controls. The group with hallucinations was characterized by a more severe cognitive impairment affecting both short‐ and long‐term memory, logical abilities, and frontal functions, while the RBD‐only group presented frontal impairment. The hypothesis that RBD in PD can be considered a risk factor not only of the hallucinations but also of more severe and diffuse cognitive abnormalities needs to be strengthened through a longitudinal evaluation. © 2005 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.20719