Increased antioxidant capacity of serum did not prevent lipid peroxidation in the intermittent ischemia-reperfusion of rat small intestine

Changes in small molecular antioxidants were followed up in a model of small intestinal ischemia in Wistar rats to evaluate their possible role in ischemic preconditioning. The superior mesenteric artery was occluded either for 60 minutes only or for 60 minutes preceded by one to three 15-minute per...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 2006-04, Vol.51 (4), p.657-661
Main Authors: CIZOVA, Hana, PAPEZIKOVA, Ivana, KUBALA, Lukas, LOJEK, Antonin, CIZ, Milan
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Antioxidants - analysis
Antioxidants - metabolism
Biological and medical sciences
Disease Models, Animal
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Intestine, Small - blood supply
Ischemia - physiopathology
Lipid Peroxidation - physiology
Luminescent Measurements
Male
Mesenteric Vascular Occlusion - blood
Mesenteric Vascular Occlusion - physiopathology
Random Allocation
Rats
Rats, Wistar
Reperfusion Injury - blood
Reperfusion Injury - physiopathology
Risk Factors
Sensitivity and Specificity
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Changes in small molecular antioxidants were followed up in a model of small intestinal ischemia in Wistar rats to evaluate their possible role in ischemic preconditioning. The superior mesenteric artery was occluded either for 60 minutes only or for 60 minutes preceded by one to three 15-minute periods of ischemia with 5-minute reperfusion periods interposed. Total antioxidant capacity (TRAP) in serum, serum antioxidants (uric acid, ascorbic acid, bilirubin), and the thiobarbituric acid reactive substances in both serum and mucosa were measured. An increase in TRAP observed after 60 minutes of ischemia was prevented in preconditioned animals. Ascorbic and uric acid concentrations increased generally in comparison to intact controls, but this increase was not sufficient to prevent lipid peroxidation in serum and intestinal mucosa. In short, the small molecular antioxidants measured did not contribute to the phenomenon of ischemic preconditioning.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-006-3188-x