Identification of EZH2 as a molecular marker for a precancerous state in morphologically normal breast tissues

The discovery of molecular markers to detect the precancerous state would have profound implications in the prevention of breast cancer. We report that the expression of the Polycomb group protein EZH2 increases in histologically normal breast epithelium with higher risk of developing cancer. We ide...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2006-04, Vol.66 (8), p.4095-4099
Main Authors: LEI DING, ERDMANN, Christine, CHINNAIYAN, Arul M, MERAJVER, Sofia D, KLEER, Celina G
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Biomarkers, Tumor - biosynthesis
Breast - cytology
Breast - metabolism
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
DNA-Binding Proteins - biosynthesis
Enhancer of Zeste Homolog 2 Protein
Female
Humans
Immunohistochemistry
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Polycomb Repressive Complex 2
Precancerous Conditions - metabolism
Precancerous Conditions - pathology
Transcription Factors - biosynthesis
Tumors
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Summary:The discovery of molecular markers to detect the precancerous state would have profound implications in the prevention of breast cancer. We report that the expression of the Polycomb group protein EZH2 increases in histologically normal breast epithelium with higher risk of developing cancer. We identify EZH2 as a potential marker for detecting preneoplastic lesions of the breast in vivo and as a possible target for preventative intervention.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-05-4300