Lack of association of cytomegalovirus with human brain tumors

Cytomegalovirus (CMV) is thought to possess oncogenic properties and has been linked with a number of human malignancies. CMV infection was recently described in association with malignant gliomas. The intent of the present study was to further investigate the reported association between CMV and ma...

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Bibliographic Details
Published in:Modern pathology 2005-06, Vol.18 (6), p.838-843
Main Authors: Lau, Sean K, Chen, Yuan-Yuan, Chen, Wen-Gang, Diamond, Don J, Mamelak, Adam N, Zaia, John A, Weiss, Lawrence M
Format: Article
Language:English
Subjects:
Brain cancer
Brain Neoplasms - pathology
Brain Neoplasms - virology
brain tumor
Cytomegalovirus
Cytomegalovirus - genetics
Cytomegalovirus - metabolism
DNA, Viral - analysis
DNA, Viral - genetics
glioma
Humans
Hybridization
Immunohistochemistry
In Situ Hybridization
Laboratory Medicine
Medicine
Medicine & Public Health
original-article
Pathology
Polymerase chain reaction
Sarcoma
Tumors
Viral infections
Viral Proteins - analysis
Viruses
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Summary:Cytomegalovirus (CMV) is thought to possess oncogenic properties and has been linked with a number of human malignancies. CMV infection was recently described in association with malignant gliomas. The intent of the present study was to further investigate the reported association between CMV and malignant gliomas. Tissue from 22 brain tumors of various histologic types and grades, four normal brains, six breast carcinomas, six colon carcinomas, six lung carcinomas, and six sarcomas were evaluated for the presence of CMV by polymerase chain reaction (PCR), in situ hybridization, and immunohistochemical methods. None of the brain tumors or normal brain tissue tested demonstrated evidence of CMV pp65 or early nuclear proteins by immunohistochemistry. In addition, no CMV RNA or DNA was detected in these cases by in situ hybridization and PCR. None of the carcinomas or sarcomas evaluated were positive for CMV by immunohistochemistry, in situ hybridization, or PCR. The findings of the present study suggest that CMV is not significantly associated with brain tumors in humans.
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.3800352