Thyroid autoantibody production is influenced by exon 1 and promoter CTLA-4 polymorphisms in patients with Hashimoto's thyroiditis

Summary Strong genetic susceptibility to thyroid autoantibody (TAb) diathesis has been shown and one of the major genes involved is probably CTLA‐4 gene. Our recent study of patients with Graves’ disease has demonstrated that exon 1 CTLA‐4 gene polymorphism influences higher TAb production. Here, we...

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Bibliographic Details
Published in:International Journal of Immunogenetics 2006-04, Vol.33 (2), p.87-91
Main Authors: Zaletel, K., Krhin, B., Gaberšček, S., Hojker, S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antigens, CD
Antigens, Differentiation - genetics
Autoantibodies - biosynthesis
CTLA-4 Antigen
Exons - genetics
Female
Hashimoto Disease - genetics
Hashimoto Disease - immunology
Hashimoto Disease - physiopathology
Humans
Male
Middle Aged
Polymorphism, Genetic
Promoter Regions, Genetic
Thyroid Gland - immunology
Thyroid Gland - metabolism
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Summary:Summary Strong genetic susceptibility to thyroid autoantibody (TAb) diathesis has been shown and one of the major genes involved is probably CTLA‐4 gene. Our recent study of patients with Graves’ disease has demonstrated that exon 1 CTLA‐4 gene polymorphism influences higher TAb production. Here, we evaluated the influence of exon 1 and promoter CTLA‐4 polymorphisms on TAb production in 109 newly diagnosed patients with Hashimoto's thyroiditis (HT). Serum TSH, thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb) were measured. 49 A/G and −318 C/T polymorphisms were detected using polymerase chain reaction amplification of genomic DNA and restriction fragment length polymorphism analysis. Patients with AG and GG genotype had significantly higher TPOAb median values compared to patients with AA genotype (P 
ISSN:1744-3121
1744-313X
1365-2370
DOI:10.1111/j.1744-313X.2006.00574.x