Cytomegalovirus enhance expression of growth factors during the development of chronic allograft nephropathy in rats

Summary Cytomegalovirus (CMV) accelerates chronic rejection (CRX) in a model of rat kidney allograft. In this model, the expressions of transforming growth factor beta 1 (TGF‐β), platelet‐derived growth factor (PDGF)‐AA, PDGF‐BB and connective tissue growth factor (CTGF) were investigated with and w...

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Bibliographic Details
Published in:Transplant international 2005-06, Vol.18 (6), p.743-749
Main Authors: Inkinen, Kaija, Soots, Anu, Krogerus, Leena, Loginov, Raisa, Bruggeman, Cathrien, Lautenschlager, Irmeli
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chronic Disease
chronic rejection
Connective Tissue Growth Factor
cytomegalovirus
Cytomegalovirus Infections - metabolism
Fibrosis
General aspects
Graft Rejection - metabolism
growth factors
Immediate-Early Proteins - analysis
Immediate-Early Proteins - genetics
Immunohistochemistry
Intercellular Signaling Peptides and Proteins - analysis
Intercellular Signaling Peptides and Proteins - genetics
kidney
Kidney - pathology
Kidney Transplantation - adverse effects
Male
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Pharmacology. Drug treatments
Platelet-Derived Growth Factor - analysis
Platelet-Derived Growth Factor - genetics
Rats
Rats, Inbred BN
Renal failure
RNA, Messenger - analysis
Transforming Growth Factor beta - analysis
Transforming Growth Factor beta - genetics
Transplantation, Homologous
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Summary:Summary Cytomegalovirus (CMV) accelerates chronic rejection (CRX) in a model of rat kidney allograft. In this model, the expressions of transforming growth factor beta 1 (TGF‐β), platelet‐derived growth factor (PDGF)‐AA, PDGF‐BB and connective tissue growth factor (CTGF) were investigated with and without CMV. Transplantations were performed under immunosuppression. One group of animals was infected with CMV and the other was left uninfected. The grafts were harvested on days 3–60 after transplantation. Growth factor proteins were demonstrated by immunohistochemistry, and mRNAs by in situ hybridization. A significantly more intense and earlier endothelial TGF‐β (2.4 ± 0.8 vs. 1.0 ± 0.0; P 
ISSN:0934-0874
1432-2277
DOI:10.1111/j.1432-2277.2005.00113.x