Chitosan hydrogel as a drug delivery carrier to control angiogenesis

An aqueous solution of photocrosslinkable chitosan containing azide groups and lactose moieties (Az-CH-LA) incorporating paclitaxel formed an insoluble hydrogel within 30 s of ultraviolet light (UV) irradiation. The chitosan hydrogel showed strong potential for use as a new tissue adhesive in surgic...

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Bibliographic Details
Published in:Journal of artificial organs 2006-03, Vol.9 (1), p.8-16
Main Authors: Ishihara, Masayuki, Obara, Kiyohaya, Nakamura, Singo, Fujita, Masanori, Masuoka, Kazunori, Kanatani, Yasuhiro, Takase, Bonpei, Hattori, Hidemi, Morimoto, Yuji, Ishihara, Miya, Maehara, Tadaaki, Kikuchi, Makoto
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Biocompatible Materials
Chitosan - chemistry
Cross-Linking Reagents
Drug Delivery Systems
Fibroblast Growth Factor 2 - administration & dosage
Fibroblast Growth Factor 2 - pharmacology
Hydrogels
Hydrogels - chemistry
Mice
Mice, Inbred Strains
Neovascularization, Pathologic - prevention & control
Occlusive Dressings
Paclitaxel - administration & dosage
Paclitaxel - pharmacology
Proteins
Rabbits
Rodents
Ultraviolet Rays
Wound Healing - physiology
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Summary:An aqueous solution of photocrosslinkable chitosan containing azide groups and lactose moieties (Az-CH-LA) incorporating paclitaxel formed an insoluble hydrogel within 30 s of ultraviolet light (UV) irradiation. The chitosan hydrogel showed strong potential for use as a new tissue adhesive in surgical applications and wound dressing. The fibroblast growth factor (FGF)-2 molecules retained in the chitosan hydrogel and in an injectable chitosan/IO(4)-heparin hydrogel remain biologically active, and were gradually released from the hydrogels as they biodegraded in vivo. The controlled release of biologically active FGF-2 molecules from the hydrogels caused induction of angiogenesis and collateral circulation occurred in healing-impaired diabetic (db/db) mice and in the ischemic limbs of rats. Paclitaxel, which is an antitumor reagent, was also retained in the chitosan hydrogel and remained biologically active as it was released on degradation of the hydrogel in vivo. The chitosan hydrogels incorporating paclitaxel effectively inhibited tumor growth and angiogenesis in mice. The purpose of this review is to describe the effectiveness of chitosan hydrogel as a local drug delivery carrier for agents (e.g., FGF-2 and paclitaxel) to control angiogenesis. It is thus proposed that chitosan hydrogel may be a promising new local carrier for drugs such as FGF-2 and paclitaxel to control vascularization.
ISSN:1434-7229
1619-0904
DOI:10.1007/s10047-005-0313-0