Improvement of Bacillus thuringiensis δ-endotoxins synthesis yields through acquisition of erythromycin resistance

The acquisition of the erythromycin resistance by Bacillus thuringiensis kurstaki improved yields of delta-endotoxins in sporulating cells ranging from 134 to 215%. Resistance to erythromycin decreased the final spore count by at least 50%. Consequently, erythromycin resistance is an efficient tool...

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Bibliographic Details
Published in:Biotechnology letters 2006-03, Vol.28 (5), p.315-319
Main Authors: TOUNSI, Slim, ZOUARI, Nabil, GHRIBI, Dhouha, J'MAL, Anis, JAOUA, Samir
Format: Article
Language:English
Subjects:
Bacillus thuringiensis - physiology
Bacterial Proteins - biosynthesis
Bacterial Proteins - genetics
Bacterial Toxins - biosynthesis
Bacterial Toxins - genetics
Biological and medical sciences
Biotechnology
Cell Proliferation - drug effects
Cell Survival - drug effects
Drug Resistance, Bacterial - drug effects
Drug Resistance, Bacterial - physiology
Endotoxins - biosynthesis
Endotoxins - genetics
Erythromycin - administration & dosage
Fundamental and applied biological sciences. Psychology
Genetic Enhancement - methods
Hemolysin Proteins - biosynthesis
Hemolysin Proteins - genetics
Protein Engineering - methods
Protein Precursors - biosynthesis
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Summary:The acquisition of the erythromycin resistance by Bacillus thuringiensis kurstaki improved yields of delta-endotoxins in sporulating cells ranging from 134 to 215%. Resistance to erythromycin decreased the final spore count by at least 50%. Consequently, erythromycin resistance is an efficient tool for the improvement of bioinsecticides yields with a high ratio of delta-endotoxins to spores.
ISSN:0141-5492
1573-6776
DOI:10.1007/s10529-005-5717-7