Evaluation of cytokines (MIG, IFN-γ, TNF-α, IL-4, IL-5, and IL-10) during the different evolutive phases of chagasic esophagopathy

The production of cytokines (MIG, IFN-γ, TNF-α, IL-4, IL-5, and IL-10) was studied in 39 individuals, including 28 with chagasic esophagopathy and 11 nonchagasic patients with gastroesophageal reflux disease. A sandwich enzyme immunoassay employing monoclonal antibody pairs specific for each cytokin...

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Bibliographic Details
Published in:Clinical Immunology 2006-05, Vol.119 (2), p.213-218
Main Authors: Crema, Eduardo, Monteiro, Isabela de Oliveira, Gomes, Marília Gabriela Zanier, Silva, Alex Augusto, Rodrigues Júnior, Virmondes
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Chagas Disease - complications
Chagas Disease - immunology
Chagas Disease - metabolism
Chagas Disease - pathology
Chagas' disease
Chemokine CXCL9
Chemokines, CXC - biosynthesis
Cytokines
Cytokines - biosynthesis
Esophageal Diseases - etiology
Esophageal Diseases - immunology
Esophageal Diseases - parasitology
Esophageal Diseases - pathology
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
IFN-γ
IL-10
IL-4
IL-5
Immunopathology
Interferon-gamma - biosynthesis
Interleukin-10 - biosynthesis
Interleukin-4 - biosynthesis
Interleukin-5 - biosynthesis
Male
Medical sciences
Megaesophagus
Middle Aged
MIG
Prospective Studies
TNF-α
Tumor Necrosis Factor-alpha - biosynthesis
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Summary:The production of cytokines (MIG, IFN-γ, TNF-α, IL-4, IL-5, and IL-10) was studied in 39 individuals, including 28 with chagasic esophagopathy and 11 nonchagasic patients with gastroesophageal reflux disease. A sandwich enzyme immunoassay employing monoclonal antibody pairs specific for each cytokine was used. IFN-γ and MIG production was significantly higher in patients with megaesophagus compared to control. Furthermore, in the absence of stimulation TNF-α levels were lower in the chagasic group than in the control group. In addition, significantly lower TNF-α levels were observed for the advanced form of the disease compared to the nonadvanced form. These results support the hypothesis that, although patients with advanced phase of megaesophagus present low number of CD4+ T lymphocytes, PBMC from this patients are able to respond up specific antigen stimulation.
ISSN:1521-6616
1521-7035
1365-2567
DOI:10.1016/j.clim.2005.12.011