Identification of new central nervous system specific mouse microRNAs

MicroRNAs (miRNAs) are small regulatory molecules suppressing mRNA activity in metazoans. Here we describe two new miRNAs cloned from brain tissue of mouse embryos. These miRNAs are expressed mainly during embryogenesis and specifically in the central nervous system. We also established the expressi...

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Bibliographic Details
Published in:FEBS letters 2006-04, Vol.580 (9), p.2195-2200
Main Authors: Wheeler, Guy, Ntounia-Fousara, Sofia, Granda, Begona, Rathjen, Tina, Dalmay, Tamas
Format: Article
Language:English
Subjects:
Animals
Asymmetrical miRNA expression
Brain - cytology
Brain - embryology
Gene Expression Regulation, Developmental - physiology
Gene Silencing - physiology
In situ hybridisation
Limb Buds - cytology
Limb Buds - embryology
Metazoa
Mice
MicroRNA
MicroRNAs - biosynthesis
MicroRNAs - genetics
Mouse brain
Organ Specificity - physiology
RNAi
Spinal Cord - cytology
Spinal Cord - embryology
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Summary:MicroRNAs (miRNAs) are small regulatory molecules suppressing mRNA activity in metazoans. Here we describe two new miRNAs cloned from brain tissue of mouse embryos. These miRNAs are expressed mainly during embryogenesis and specifically in the central nervous system. We also established the expression patterns of three recently identified miRNAs that were found in our short RNA library. All of them were expressed in the brain and spinal chord but while miR-410 and miR-431 were central nervous system specific, miR-500 was also expressed in limb buds. In addition, the expression of miR-500 in limb buds showed very strong asymmetry in favour of the left hand side.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2006.03.019