Nodal Flow and the Generation of Left-Right Asymmetry

The establishment of left-right asymmetry in mammals is a good example of how multiple cell biological processes coordinate in the formation of a basic body plan. The leftward movement of fluid at the ventral node, called nodal flow, is the central process in symmetry breaking on the left-right axis...

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Bibliographic Details
Published in:Cell 2006-04, Vol.125 (1), p.33-45
Main Authors: Hirokawa, Nobutaka, Tanaka, Yosuke, Okada, Yasushi, Takeda, Sen
Format: Article
Language:English
Subjects:
Animals
Body Patterning
Calcium Signaling
Embryo, Mammalian - embryology
Embryo, Mammalian - metabolism
Embryo, Nonmammalian
Gene Expression Regulation, Developmental
Hedgehog Proteins
Organizers, Embryonic - embryology
Trans-Activators - metabolism
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Summary:The establishment of left-right asymmetry in mammals is a good example of how multiple cell biological processes coordinate in the formation of a basic body plan. The leftward movement of fluid at the ventral node, called nodal flow, is the central process in symmetry breaking on the left-right axis. Nodal flow is autonomously generated by the rotation of cilia that are tilted toward the posterior on cells of the ventral node. These cilia are built by transport via the KIF3 motor complex. How nodal flow is interpreted to create left-right asymmetry has been a matter of debate. Recent evidence suggests that the leftward movement of membrane-sheathed particles, called nodal vesicular parcels (NVPs), may result in the activation of the noncanonical Hedgehog signaling pathway, an asymmetric elevation in intracellular Ca 2+ and changes in gene expression.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2006.03.002