Vascular endothelial growth factor antagonist reduces brain edema formation and venous infarction

Cerebral venous ischemia often induces severe brain edema. Vascular endothelial growth factor (VEGF), which induces angiogenesis, is also known as vascular permeability (VP) factor. The present study was undertaken to investigate whether the inhibition of VEGF could reduce brain edema formation and...

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Bibliographic Details
Published in:Stroke (1970) 2005-06, Vol.36 (6), p.1259-1263
Main Authors: KIMURA, R, NAKASE, H, TAMAKI, R, SAKAKI, T
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - pathology
Brain Infarction - drug therapy
Brain Ischemia - pathology
Cerebral Infarction
Cytoplasm - metabolism
Edema - drug therapy
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Ischemia - drug therapy
Ischemia - pathology
Light
Magnetic Resonance Imaging
Male
Medical sciences
Neovascularization, Physiologic
Nervous system
Neurology
Neurons - metabolism
Neuropharmacology
Neuroprotective agent
Pharmacology. Drug treatments
Phosphates - pharmacology
Rats
Rats, Wistar
Thrombosis
Ultrasonic investigative techniques
Vascular diseases and vascular malformations of the nervous system
Vascular Endothelial Growth Factor A - antagonists & inhibitors
Vascular Endothelial Growth Factor A - metabolism
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Summary:Cerebral venous ischemia often induces severe brain edema. Vascular endothelial growth factor (VEGF), which induces angiogenesis, is also known as vascular permeability (VP) factor. The present study was undertaken to investigate whether the inhibition of VEGF could reduce brain edema formation and cerebral venous infarction (CVI) in a rat 2-vein occlusion (2-VO) model. We used 2-VO model in which 2 adjacent cortical veins were photochemically occluded. Male Wistar rats (n=25) were divided into 2 groups: one group was treated with a VEGF antagonist (antagonist group, n=10) and the second group was treated with phosphate-buffered solution (PBS) (PBS group, n=15). VEGF antagonist or PBS was injected intraperitoneally immediately after 2-VO. The developing ischemic infarct was evaluated by magnetic resonance imaging (MRI) and histology 24 hours after occlusion. VEGF expression was observed in the cytoplasm of neurons exclusively in the area of vasogenic edema that was shown as a high-intensity area in the apparent diffusion coefficient of water map. Ischemic volumes calculated from each MR images, which are related to infarction and/or vasogenic edema, respectively, were significantly smaller in the antagonist group as compared with the PBS group (P
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.0000165925.20413.14