Protein biochips: A new and versatile platform technology for molecular medicine

The multi-parallel possibilities of protein array applications have the potential not only to allow the optimization of pre-clinical, toxicological and clinical studies through better selection and stratification of individuals, but also to affect how diagnostics are used in drug development. The hu...

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Bibliographic Details
Published in:Drug discovery today 2005-06, Vol.10 (11), p.789-794
Main Authors: Lueking, Angelika, Cahill, Dolores J., Müllner, Stefan
Format: Article
Language:English
Subjects:
Animals
Antibody profiling
BIACORE
Biological and medical sciences
General pharmacology
Humans
Immunomics
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Protein Array Analysis - methods
Protein Array Analysis - trends
Protein microarray
Protein-peptide interactions
Proteomics - methods
Proteomics - trends
Technology, Pharmaceutical - trends
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Summary:The multi-parallel possibilities of protein array applications have the potential not only to allow the optimization of pre-clinical, toxicological and clinical studies through better selection and stratification of individuals, but also to affect how diagnostics are used in drug development. The human genome has been sequenced and the challenges of understanding the function of the newly discovered genes have been addressed. High-throughput technologies such as DNA microarrays have been developed for the profiling of gene expression patterns in whole organisms or tissues. Protein arrays are emerging to follow DNA chips as possible screening tools. Here, we review the generation and application of microarray technology to obtain more information on the regulation of proteins, their biochemical functions and their potential interaction partners. Already, a large variety of assays based on antibody-antigen interactions exists. In addition, the medical relevance of protein arrays will be discussed.
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(05)03449-5