Investigating the post-chemiluminescence behavior of phenothiazine medications in the luminol-potassium ferricyanide system: molecular imprinting-post-chemiluminescence method for the determination of chlorpromazine hydrochloride

A new post-chemiluminescence (PCL) phenomenon was observed when phenothiazine medications were injected into the reaction mixture after the chemiluminescence (CL) reaction of luminol and potassium ferricyanide had finished. A possible reaction mechanism was proposed based on studies of the kinetic c...

Full description

Saved in:
Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2006-05, Vol.385 (1), p.153-160
Main Authors: Niu, Weifen, Feng, Na, Nie, Fei, Lu, Jiuru
Format: Article
Language:English
Subjects:
Animals
Antipsychotic Agents - chemistry
Chemiluminescence
Chlorpromazine
Chlorpromazine - analysis
Chlorpromazine - urine
Chlorpromazine hydrochloride
Correlation coefficient
Correlation coefficients
Drinking water
Ferricyanides - chemistry
Imprinted polymers
Luminescence
Luminol - chemistry
Molecular imprinted polymer (MIP)
Molecular imprinting
Phenothiazine
Phenothiazine medications
Phenothiazines - chemistry
Polymers
Post-chemiluminescence (PCL)
Potassium
Potassium ferricyanide
Reaction mechanisms
Selectivity
Sensitivity and Specificity
Spectra
Water - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new post-chemiluminescence (PCL) phenomenon was observed when phenothiazine medications were injected into the reaction mixture after the chemiluminescence (CL) reaction of luminol and potassium ferricyanide had finished. A possible reaction mechanism was proposed based on studies of the kinetic characteristics of the CL, CL spectra, fluorescence spectra, and on other experiments. The feasibility of determining various phenothiazine medications by utilizing these PCL reactions was examined. A molecular imprinting-post-chemiluminescence (MI-PCL) method was established for the determination of chlorpromazine hydrochloride using a chlorpromazine hydrochloride-imprinted polymer (MIP) as the recognition material. The method displayed high selectivity and high sensitivity. The linear range of the method was 1.0x10-⁸~1.0x10-⁶, with a linear correlation coefficient of 0.9985. The detection limit was 3x10-⁹ g/ml chlorpromazine hydrochloride, and the relative standard deviation for a 1.0x10-⁷ g/ml chlorpromazine hydrochloride solution was 4.0% (n=11). The method has been applied to the determination of chlorpromazine hydrochloride in urine and animal drinking water with satisfactory results. [graphic removed]
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-006-0365-x