Elevation of plasma osteopontin level in patients with undifferentiated nasopharyngeal carcinoma

We evaluated the clinicopathologic relevance of plasma osteopontin (OPN) level in nasopharyngeal carcinoma patients. Seventy-two plasma samples were collected from patients with undifferentiated nasopharyngeal carcinoma (NPC) before radiotherapy. Plasma OPN level was determined by quantitative sandw...

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Bibliographic Details
Published in:European journal of surgical oncology 2005-06, Vol.31 (5), p.555-558
Main Authors: Wong, T S, Kwong, D L-W, Sham, J, Wei, W I, Kwong, Y L, Yuen, A P-W
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - blood
Female
Humans
Male
Middle Aged
Nasopharyngeal Neoplasms - blood
Nasopharyngeal Neoplasms - pathology
Neoplasm Staging
Osteopontin
Sialoglycoproteins - blood
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Summary:We evaluated the clinicopathologic relevance of plasma osteopontin (OPN) level in nasopharyngeal carcinoma patients. Seventy-two plasma samples were collected from patients with undifferentiated nasopharyngeal carcinoma (NPC) before radiotherapy. Plasma OPN level was determined by quantitative sandwich enzyme immunoassay. The plasma OPN level was evaluated for its clinicopathologic relevance. The mean plasma OPN level was significantly higher in NPC patients than in normal controls (184.66 vs 75.89 ng/ml, p
ISSN:0748-7983
DOI:10.1016/j.ejso.2005.01.005