Ovariectomy increases Na +, K +-ATPase, acetylcholinesterase and catalase in rat hippocampus

In the present work we investigated the effect of ovariectomy on Na +, K +-ATPase and acetylcholinesterase (AChE) activities in rat hippocampus. We also studied some parameters of oxidative stress, namely total radical-trapping antioxidant potential (TRAP), thiobarbituric acid-reactive substances (T...

Full description

Saved in:
Bibliographic Details
Published in:Molecular and cellular endocrinology 2005-05, Vol.236 (1), p.9-16
Main Authors: Monteiro, Siomara C., Matté, Cristiane, Delwing, Daniela, Wyse, Angela T.S.
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Acetylcholinesterase - metabolism
Animals
Biomarkers - analysis
Catalase
Catalase - metabolism
Female
Female rats
Hippocampus
Hippocampus - enzymology
Hippocampus - metabolism
Na +, K +-ATPase
Ovariectomy
Oxidative Stress
Postmenopause - metabolism
Rats
Rats, Wistar
Sodium-Potassium-Exchanging ATPase - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the present work we investigated the effect of ovariectomy on Na +, K +-ATPase and acetylcholinesterase (AChE) activities in rat hippocampus. We also studied some parameters of oxidative stress, namely total radical-trapping antioxidant potential (TRAP), thiobarbituric acid-reactive substances (TBA-RS), as well as the antioxidant enzyme activities superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities. Our hypothesis is that ovariectomy might cause alterations in essential enzyme activities necessary to brain normal functioning and that these chances could be caused by oxidative stress. Female adult Wistar rats were divided into three groups: (1) naïve (control); (2) sham-operated; and (3) ovariectomized. Thirty days after ovariectomy rats were sacrificed. Results showed that rats subjected to ovariectomy presented a significant increase in Na +, K +-ATPase, AChE and CAT activities, but did not change the oxidative stress parameters studied when compared to sham or naïve rats. Since ovariectomy mimics postmenopausal changes, our findings showing alteration in the activities of brain Na +, K +-ATPase, AChE and CAT may be related to problems in postmenopausal women.
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2005.03.006