Microbial Transformation of 20(S)-Protopanaxatriol by Mucor spinosus

Microbial biotransformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus (AS 3.3450) yielded four new metabolites, the structures of which were determined to be 12-oxo-15alpha-hydroxyl-20(S)-protopanaxatriol (2), 27-hydroxyl-20(S)-protopanaxatriol (3), 12-oxo-26-hydroxyl-20(S)-protopan...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-05, Vol.68 (5), p.678-680
Main Authors: TIAN, Yin, GUO, Hongzhu, HAN, Jian, GUO, Dean
Format: Article
Language:English
Subjects:
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Applied microbiology
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Biotransformation
Chemotherapic agents
Drug Screening Assays, Antitumor
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Microbiology
Molecular Structure
Mucor - metabolism
Sapogenins - metabolism
Sapogenins - pharmacology
Stereoisomerism
Triterpenes - metabolism
Triterpenes - pharmacology
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Summary:Microbial biotransformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus (AS 3.3450) yielded four new metabolites, the structures of which were determined to be 12-oxo-15alpha-hydroxyl-20(S)-protopanaxatriol (2), 27-hydroxyl-20(S)-protopanaxatriol (3), 12-oxo-26-hydroxyl-20(S)-protopanaxatriol (4), and 12-oxo-27-hydroxyl-20(S)-protopanaxatriol (5), respectively, on the basis of their chemical and spectroscopic data. All the new metabolites, as well as the substrate, had significant cytotoxic effects on HL-60 cells (human leukemia cells).
ISSN:0163-3864
1520-6025
DOI:10.1021/np049688+