Islet Transplantation: Progress and Challenge

For over 30 years, investigators have explored islet transplantation as a logical approach to restoring glucose homeostasis in persons with diabetes. Islet transplantation can currently provide improved glycemic control, relief from recurrent severe hypoglycemia, and potentially insulin independence...

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Bibliographic Details
Published in:Archives of medical research 2005-05, Vol.36 (3), p.273-280
Main Authors: Gaglia, Jason L., Shapiro, A.M. James, Weir, Gordon C.
Format: Article
Language:English
Subjects:
Animals
Clinical Trials as Topic
Diabetes Mellitus, Type 1 - therapy
Glucose - metabolism
Humans
Hypoglycemia
Immunosuppressive Agents - pharmacology
Insulin - metabolism
Islet transplantation
Islets of Langerhans Transplantation - instrumentation
Islets of Langerhans Transplantation - methods
Pancreas Transplantation - methods
Time Factors
Type 1 diabetes
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Description
Summary:For over 30 years, investigators have explored islet transplantation as a logical approach to restoring glucose homeostasis in persons with diabetes. Islet transplantation can currently provide improved glycemic control, relief from recurrent severe hypoglycemia, and potentially insulin independence. In this review, we describe details of the evolution of modern islet transplantation and provide insight into ongoing clinical and basic research efforts to overcome current obstacles for this promising therapy.
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2005.03.014