Mammalian microRNAs derived from genomic repeats

In this article, we show that a subset of conventional mammalian microRNAs is derived from LINE-2 transposable elements and other genome repeats. These repeat-derived microRNAs arise from conventional precursor hairpins and are distinct from the rasiRNAs, which appear to be processed from long doubl...

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Bibliographic Details
Published in:Trends in genetics 2005-06, Vol.21 (6), p.322-326
Main Authors: Smalheiser, Neil R., Torvik, Vetle I.
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biological and medical sciences
Computational Biology
DNA Transposable Elements
Expressed Sequence Tags
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Humans
Long Interspersed Nucleotide Elements
Mice
MicroRNAs - genetics
Molecular and cellular biology
Molecular Sequence Data
Rats
Repetitive Sequences, Nucleic Acid
RNA, Messenger - genetics
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Summary:In this article, we show that a subset of conventional mammalian microRNAs is derived from LINE-2 transposable elements and other genome repeats. These repeat-derived microRNAs arise from conventional precursor hairpins and are distinct from the rasiRNAs, which appear to be processed from long double-stranded RNA precursors. The insertion of transposable elements into new genomic sites appears to be one of the driving-forces that create new microRNAs during mammalian evolution. Two of the LINE-2-derived microRNAs exhibit perfect complementarity to a large family of mRNA and EST transcripts that contain portions of MIR and other LINE-2 elements in their 3′-untranslated regions.
ISSN:0168-9525
DOI:10.1016/j.tig.2005.04.008