The anti-inflammatory effects of IV administered clenbuterol in horses with recurrent airway obstruction

Cyclic AMP elevating agents have been shown to exhibit anti-inflammatory properties in addition to functions such as bronchodilation. The aim of this study was to investigate this dual action of clenbuterol (CB; Ventipulmin) on horses affected with recurrent airway obstruction (RAO). Seven RAO susce...

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Bibliographic Details
Published in:The veterinary journal (1997) 2006-05, Vol.171 (3), p.429-437
Main Authors: Laan, Tamarinde T.J.M., Bull, Sarah, Pirie, R. Scott, Fink-Gremmels, Johanna
Format: Article
Language:English
Subjects:
Alveolar macrophage
Animals
Anti-inflammatory
anti-inflammatory activity
Antigens, Fungal - pharmacology
Aspergillus fumigatus
bronchoalveolar lavage fluid
Bronchoalveolar Lavage Fluid - cytology
bronchodilation
Bronchodilator Agents - therapeutic use
Clenbuterol
Clenbuterol - therapeutic use
cyclic AMP
Cytokines - metabolism
Dust
Female
fungal antigens
hay
hay dust
Horse
horse diseases
Horse Diseases - drug therapy
Horse Diseases - immunology
Horses
inflammation
Injections, Intravenous - veterinary
intravenous injection
lipopolysaccharides
Lipopolysaccharides - pharmacology
Lung Diseases, Obstructive - drug therapy
Lung Diseases, Obstructive - immunology
Lung Diseases, Obstructive - veterinary
Macrophages, Alveolar - metabolism
Male
mechanism of action
neutrophils
plate count
Random Allocation
RAO
recurrent airway obstruction
respiratory tract diseases
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Summary:Cyclic AMP elevating agents have been shown to exhibit anti-inflammatory properties in addition to functions such as bronchodilation. The aim of this study was to investigate this dual action of clenbuterol (CB; Ventipulmin) on horses affected with recurrent airway obstruction (RAO). Seven RAO susceptible horses received inhalation challenges with aerosolised lipopolysaccharide (LPS), hay dust suspension (HDS) and Aspergillus fumigatus antigen (AF) with and without prior treatment with intravenous CB. Data showed that CB exerted significant beneficial effects on lung function, total cell count (TCC) and bronchoalveolar lavage neutrophil influx. In addition, CB significantly decreased the expression of several pro-inflammatory cytokines and chemokines in the alveolar macrophages of RAO-susceptible horses after challenge with LPS and HDS, and increased the expression of interleukin-6, known to act as a pro-and anti-inflammatory cytokine, following different challenges. This anti-inflammatory activity of CB is of additive value to its currently recognised use in equine RAO.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2005.02.019