Emergence of Drug-Resistant Influenza Virus: Population Dynamical Considerations

Given the considerable challenges to the rapid development of an effective vaccine against influenza, antiviral agents will play an important role as a first-line defense if a new pandemic occurs. The large-scale use of drugs for chemoprophylaxis and treatment will impose strong selection for the ev...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2006-04, Vol.312 (5772), p.389-391
Main Authors: Regoes, Roland R, Bonhoeffer, Sebastian
Format: Article
Language:English
Subjects:
Acetamides - pharmacology
Acetamides - therapeutic use
Amantadine - pharmacology
Amantadine - therapeutic use
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Antivirals
Biological and medical sciences
Computer Simulation
Disease models
Disease Outbreaks
Disease transmission
Drug design
Drug resistance
Drug Resistance, Viral - genetics
Epidemics
Epidemiology
Fundamental and applied biological sciences. Psychology
Human viral diseases
Humans
Infectious diseases
Influenza
Influenza A virus - drug effects
Influenza A virus - genetics
Influenza A virus - pathogenicity
Influenza virus
Influenza, Human - drug therapy
Influenza, Human - epidemiology
Influenza, Human - prevention & control
Influenza, Human - virology
Mathematics
Medical sciences
Microbiology
Models, Biological
Mutation
Neuraminidase - antagonists & inhibitors
Orthomyxoviridae - drug effects
Orthomyxoviridae - genetics
Orthomyxoviridae - pathogenicity
Oseltamivir
Pandemics
Perspectives
Population Dynamics
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Vaccination
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Virology
Viruses
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Summary:Given the considerable challenges to the rapid development of an effective vaccine against influenza, antiviral agents will play an important role as a first-line defense if a new pandemic occurs. The large-scale use of drugs for chemoprophylaxis and treatment will impose strong selection for the evolution of drug-resistant strains. The ensuing transmission of those strains could substantially limit the effectiveness of the drugs as a first-line defense. Summarizing recent data on the rate at which the treatment of influenza infection generates resistance de novo and on the transmission fitness of resistant virus, we discuss possible implications for the epidemiological spread of drug resistance in the context of an established population dynamic model.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1122947