Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase

An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases α and β and human terminal deoxynucleotidyl transf...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2006-06, Vol.16 (11), p.2877-2881
Main Authors: Doncaster, Jeremy R., Etchells, Laura L., Kershaw, Neil M., Nakamura, Ryoichi, Ryan, Hazel, Takeuchi, Ryo, Sakaguchi, Kengo, Sardarian, Ali, Whitehead, Roger C.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biological Products - chemical synthesis
Biological Products - chemistry
Biological Products - pharmacology
Biomimetic synthesis
DNA Nucleotidylexotransferase - metabolism
DNA polymerase
DNA-Directed DNA Polymerase - metabolism
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Humans
Medical sciences
Miscellaneous
Molecular Structure
Natural products
Nucleic Acid Synthesis Inhibitors
Oxylipins
Pharmacology. Drug treatments
Structure-Activity Relationship
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Summary:An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases α and β and human terminal deoxynucleotidyl transferase (TdT).
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.03.005