Reclassification of oligoastrocytomas by loss of heterozygosity studies

Oligoastrocytomas (OAs) are WHO grade II or III tumors composed of a mixture of 2 neoplastic cell types morphologically resembling the cells in oligodendrogliomas and diffuse astrocytomas. Investigations on the genetic profile of OAs may yield important information for their classification and help...

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Bibliographic Details
Published in:International journal of cancer 2006-07, Vol.119 (1), p.84-90
Main Authors: Eoli, Marica, Bissola, Lorena, Bruzzone, Maria Grazia, Pollo, Bianca, Maccagnano, Carmelo, De Simone, Tiziana, Valletta, Lorella, Silvani, Antonio, Bianchessi, D, Broggi, Giovanni, Boiardi, Amerigo, Finocchiaro, Gaetano
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Astrocytoma - classification
Astrocytoma - genetics
Astrocytoma - pathology
Astrocytoma - surgery
Biological and medical sciences
Brain Neoplasms - classification
Brain Neoplasms - genetics
Brain Neoplasms - pathology
Brain Neoplasms - surgery
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 19
Disease Progression
Disease-Free Survival
Female
Humans
LOH 10
LOH 17p
LOH 19q
LOH 1p
Loss of Heterozygosity
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
MRI
Neurology
oligoastrocytoma
Survival Analysis
Tumors
Tumors of the nervous system. Phacomatoses
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Summary:Oligoastrocytomas (OAs) are WHO grade II or III tumors composed of a mixture of 2 neoplastic cell types morphologically resembling the cells in oligodendrogliomas and diffuse astrocytomas. Investigations on the genetic profile of OAs may yield important information for their classification and help for their clinical management. We have studied, in 94 OAs (46 WHO grade II and 48 WHO grade III), the patterns of loss of heterozygosity (LOH) of 4 genomic regions: 1p, 19q, 17p and 10q. Results were as follows: LOH 1p was present in 46% of the tumors; LOH 19q in 45%; LOH 17p in 22%; LOH 10q in 16%. LOH 1p and 19q were associated in 32%, other LOH associations were rare (
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.21759