New genes in inflammatory bowel disease: lessons for complex diseases?

The chronic inflammatory bowel diseases Crohn's disease and ulcerative colitis are common causes of gastrointestinal disease in northern Europe, affecting as many as one in 250 people. Although mortality is low, morbidity associated with these diseases is substantial. We review the recent advan...

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Bibliographic Details
Published in:The Lancet (British edition) 2006-04, Vol.367 (9518), p.1271-1284
Main Authors: Gaya, Daniel R, Russell, Richard K, Nimmo, Elaine R, Satsangi, Jack
Format: Article
Language:English
Subjects:
Animals
ATP-Binding Cassette, Sub-Family B, Member 1 - genetics
ATP-Binding Cassette, Sub-Family B, Member 1 - physiology
Biological and medical sciences
Bowel disease
Colitis, Ulcerative - genetics
Crohn Disease - genetics
Europe - epidemiology
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Genes
Genetic Predisposition to Disease
Genetics
Genetics, Population
Genotype & phenotype
Humans
Inflammatory bowel disease
Inflammatory Bowel Diseases - epidemiology
Inflammatory Bowel Diseases - genetics
Medical research
Medical sciences
Mutation
Other diseases. Semiology
Phenotype
Population genetics
Sample size
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Toll-Like Receptor 4 - genetics
Twins
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Description
Summary:The chronic inflammatory bowel diseases Crohn's disease and ulcerative colitis are common causes of gastrointestinal disease in northern Europe, affecting as many as one in 250 people. Although mortality is low, morbidity associated with these diseases is substantial. We review the recent advances in the genetics of inflammatory bowel disease, with particular emphasis on the data that have been generated since the discovery of the CARD15 (NOD2) gene in 2001.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(06)68345-1