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Analysis of cytokine levels in cerebrospinal fluid in mumps meningitis: Comparison with echovirus type 30 meningitis
It is unclear whether or not the CSF cytokine profiles in viral meningitis differ with the kind of causative virus. We measured the concentrations of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), IL-4, IL-6, and IL-10 in CSF during the acute stage in 15 children with m...
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Published in: | Cytokine (Philadelphia, Pa.) Pa.), 2005-06, Vol.30 (5), p.243-247 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | It is unclear whether or not the CSF cytokine profiles in viral meningitis differ with the kind of causative virus.
We measured the concentrations of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), IL-4, IL-6, and IL-10 in CSF during the acute stage in 15 children with mumps meningitis (MM), and 34 with echovirus type 30 meningitis (EM).
The CSF IFN-γ, IL-2, IL-6, and IL-10 levels were elevated in MM, and the CSF IFN-γ, IL-2, and IL-6 levels were elevated in EM. The CSF IFN-γ, IL-2, and IL-10 levels in MM were significantly higher than those in EM (
p
<
0.0001,
p
<
0.0001, and
p
<
0.0001, respectively). The CSF IL-6 levels in EM were significantly higher than those in MM (
p
=
0.0255). The CSF TNF-α and IL-4 levels were not elevated in MM or EM. In MM, the IL-6 level was correlated with the IL-2 and IL-10 levels in CSF (
p
=
0.0347 and
p
=
0.0120, respectively). In EM, the IFN-γ level was correlated with the IL-10 level in CSF (
p
=
0.0002).
CSF cytokine profiles in MM were different from those in EM. Therefore, it is likely that the pathogenesis of MM is different from that of EM. |
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ISSN: | 1043-4666 1096-0023 |
DOI: | 10.1016/j.cyto.2005.01.022 |